Evidence map›Paper›PMID 30013928›Full record

ArticleNeuroImage. Clinical2018

Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy.

Olga Laporta-Hoyos, Simona Fiori, Kerstin Pannek, Júlia Ballester-Plané, David Leiva, Lee B Reid, Alex M Pagnozzi, Élida Vázquez, Ignacio Delgado, Alfons Macaya and 2 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05654350 (The Relationship Between Lesion Site And Neglect Anosognosia in Right Hemispheric Stroke Patients With Left Hemispatial Neglect), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05654350 completednot on this mapstarted 2022, after this paper: background citation

The Relationship Between Lesion Site And Neglect Anosognosia in Right Hemispheric Stroke Patients With Left Hemispatial Neglect

TypeobservationalSponsorGazi UniversityRan2022 to 2023Enrolled78ConditionsAnosognosia, Neglect, Hemispatial, Stroke, Neurobehavioral Problems
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Olga Laporta-HoyosDepartament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Barcelona, Spain; IRCCS Fondazione Stella Maris, Pisa, Italy; Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation, Brisbane, Australia.
Simona FioriIRCCS Fondazione Stella Maris, Pisa, Italy.
Kerstin PannekAustralian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation, Brisbane, Australia.
Júlia Ballester-PlanéDepartament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Barcelona, Spain; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain; Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
David LeivaDepartament de Psicologia Social i Psicologia Quantitativa, Universitat de Barcelona, Barcelona, Spain.
Lee B ReidAustralian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation, Brisbane, Australia.
Alex M PagnozziAustralian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation, Brisbane, Australia.
Élida VázquezServei de Radiologia Pediàtrica, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Ignacio DelgadoServei de Radiologia Pediàtrica, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Alfons MacayaGrup de Recerca en Neurologia Pediàtrica, Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain.
Roser PueyoDepartament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Barcelona, Spain; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain; Institut de Recerca Sant Joan de Déu, Barcelona, Spain. Electronic address: rpueyo@ub.edu.
Roslyn N BoydQueensland Cerebral Palsy and Rehabilitation Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Commonwealth Scientific and Industrial Research Organisation · AUInstitut de Recerca Sant Joan de DéuVall d'Hebron Hospital Universitari · ESFondazione Stella Maris · ITThe University of Queensland · AUUniversitat Autònoma de Barcelona · ESUniversitat de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To characterise brain lesions in dyskinetic cerebral palsy (DCP) using the semi-quantitative scale for structural MRI (sqMRI) and to investigate their relationship with motor, communication and cognitive function. Materials and methods: Thirty-nine participants (19 females, median age 21y) with DCP were assessed in terms of motor function, communication and a variety of cognitive domains. Whole-head magnetic resonance imaging (MRI) was performed including T1-MPRAGE, T2 turbo spin echo (axial plane), and fluid attenuated inversion recovery images (FLAIR). A child neurologist visually assessed images for brain lesions and scored these using the sqMRI. Ordinal, Poisson and binomial negative regression models identified which brain lesions accounted for clinical outcomes. Results: Brain lesions were most frequently located in the ventral posterior lateral thalamus and the frontal lobe. Gross (B = 0.180, Conclusions: Key clinical outcomes in DCP are associated with specific observable brain lesions as indexed by a simple lesion scoring system that relies only on standard clinical MRI.

Indexed as

CommunicationAdolescentAdultBrainCerebral PalsyChildCognitionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMotor ActivitySeverity of Illness IndexYoung AdultCerebral palsy, (CP)CommunicationDyskinetic cerebral palsyDyskinetic cerebral palsy, (DCP)Fluid attenuated inversion recovery images, (FLAIR)Frontal lobeGross motor function classification system, (GMFCS)Intellectual functioningMagnetic resonance images, (MRI)Semi-quantitative scale for brain structural MRI, (sqMRI)Ventral posterior lateral thalamusVisuoperception

Identifiers

PMID30013928
PMCPMC6019264
OpenAlexW2808523868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.