Evidence map›Paper›PMID 30013913›Full record

Trial reportNeuroImage. Clinical2018

Which of the branched-chain amino acids increases cerebral blood flow in hepatic encephalopathy? A double-blind randomized trial.

Fernando Gomes Romeiro, Marjorie do Val Ietsugu, Letícia de Campos Franzoni, Laís Augusti, Matheus Alvarez, Lívia Alves Amaral Santos, Talles Bazeia Lima, Kátia Hiromoto Koga, Sônia Marta Moriguchi, Carlos Antonio Caramori and 2 more

Erratum issuedOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Fernando Gomes RomeiroDepartment of Internal Medicine, Botucatu Medical School, UNESP - Univ Estadual Paulista. Av. Prof. Mário Rubens Guimarães Montenegro, s/n Distrito de Rubião Jr, Botucatu, São Paulo 18618-687, Brazil. Electronic address: fgromeiro@fmb.unesp.br.
Marjorie do Val IetsuguDepartment of Internal Medicine, Botucatu Medical School, UNESP - Univ Estadual Paulista. Av. Prof. Mário Rubens Guimarães Montenegro, s/n Distrito de Rubião Jr, Botucatu, São Paulo 18618-687, Brazil.
Letícia de Campos FranzoniDepartment of Internal Medicine, Botucatu Medical School, UNESP - Univ Estadual Paulista. Av. Prof. Mário Rubens Guimarães Montenegro, s/n Distrito de Rubião Jr, Botucatu, São Paulo 18618-687, Brazil.
Laís AugustiDepartment of Internal Medicine, Botucatu Medical School, UNESP - Univ Estadual Paulista. Av. Prof. Mário Rubens Guimarães Montenegro, s/n Distrito de Rubião Jr, Botucatu, São Paulo 18618-687, Brazil.
Matheus AlvarezDepartment of Physics and Biophysics, Botucatu Biosciences Institute, UNESP - Univ Estadual Paulista, Rua Prof. Dr. Antonio Celso Wagner Zanin, s/n, Botucatu, São Paulo 18618-689, Brazil. Electronic address: matheus@consult.med.br.
Lívia Alves Amaral SantosDepartment of Internal Medicine, Botucatu Medical School, UNESP - Univ Estadual Paulista. Av. Prof. Mário Rubens Guimarães Montenegro, s/n Distrito de Rubião Jr, Botucatu, São Paulo 18618-687, Brazil.
Talles Bazeia LimaDepartment of Internal Medicine, Botucatu Medical School, UNESP - Univ Estadual Paulista. Av. Prof. Mário Rubens Guimarães Montenegro, s/n Distrito de Rubião Jr, Botucatu, São Paulo 18618-687, Brazil.
Kátia Hiromoto KogaDepartment of Tropical Diseases and Imaging Diagnosis, Botucatu Medical School, UNESP - Univ Estadual Paulista, Av. Prof. Mário Rubens Guimarães Montenegro, s/n. Distrito de Rubião Jr, Botucatu, São Paulo 18618-687, Brazil. Electronic address: khkoga@fmb.unesp.br.
Sônia Marta MoriguchiDepartment of Tropical Diseases and Imaging Diagnosis, Botucatu Medical School, UNESP - Univ Estadual Paulista, Av. Prof. Mário Rubens Guimarães Montenegro, s/n. Distrito de Rubião Jr, Botucatu, São Paulo 18618-687, Brazil.
Carlos Antonio CaramoriDepartment of Internal Medicine, Botucatu Medical School, UNESP - Univ Estadual Paulista. Av. Prof. Mário Rubens Guimarães Montenegro, s/n Distrito de Rubião Jr, Botucatu, São Paulo 18618-687, Brazil.
Giovanni Faria SilvaDepartment of Internal Medicine, Botucatu Medical School, UNESP - Univ Estadual Paulista. Av. Prof. Mário Rubens Guimarães Montenegro, s/n Distrito de Rubião Jr, Botucatu, São Paulo 18618-687, Brazil. Electronic address: giovanni@fmb.unesp.br.
Luiz Eduardo Gomes Garcia BettingDepartment of Neurology, Psychology and Psychiatry, Botucatu Medical School, UNESP - Univ Estadual Paulista, Av. Prof. Mário Rubens Guimarães Montenegro, s/n Distrito de Rubião Jr, Botucatu, São Paulo 18618-687, Brazil. Electronic address: betting@fmb.unesp.br.
Universidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Branched-chain amino acids increase the brain perfusion of patients with hepatic encephalopathy (HE), but the amino acid and the mechanisms involved are still unknown. This study compared brain perfusion and clinical improvement during leucine or isoleucine supplementation. After randomization, 27 subjects with cirrhosis and HE received leucine or isoleucine supplements for one year. Brain single Photon Emission Computed Tomography (SPECT) and dynamic brain scintigraphy (DBS) were performed pretreatment and at 1, 8 and 12 months of supplementation. Brain perfusion was increased only in the isoleucine group at 8 months of treatment by both SPECT and DBS (

Indexed as

AgedBrainCerebrovascular CirculationDouble-Blind MethodFemaleHepatic EncephalopathyHumansIsoleucineLeucineMaleMiddle AgedTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonTreatment OutcomeIsoleucineLeucineAC, arm circumferenceAPMT, adductor pollicis muscle thicknessBCAA, branched-chain amino acidsBCKA, branched-chain ketoacidsBMI, body mass indexBranched-chain amino acidsCAMA, corrected mid-arm muscle areaCBF, cerebral blood flowCerebral blood flowEEG, electroencephalogramFDR, false discovery rateGDH, glutamate dehydrogenaseGLN, glutamineGLU, glutamateHE, hepatic encephalopathyHepatic encephalopathyHGS, handgrip strengthHPLC, high-performance liquid chromatographyHRQoL, health-related quality of lifeLiver cirrhosisMAMC, mid-arm muscle circumferenceMELD, Model of End-Stage Liver DiseaseNH3, ammoniaPDH, pyruvate dehydrogenase complexROIs, regions of interestROS, reactive oxygen speciesSF-36, 36-item Short-Form General Health SurveySPECT, Single Photon Emission Computed TomographySPM12, Statistical Parametrical Mapping 12TCA, tricarboxylic acidTSF, triceps skinfoldαKGDH, α-ketoglutarate dehydrogenase complexα-KG, α-ketoglutarate

Identifiers

PMID30013913
PMCPMC6044187
OpenAlexW2795119947

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.