ArticlePeerJ2018
Experimental evolution of UV resistance in a phage.
Article in PeerJ, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Design of a Bacteriophage-Based Product for Biocontrol of Fire Blight and Black Rot.Microbial biotechnology · 2026Article
- Single capsid mutations modulating phage adsorption, persistence, and plaque morphology shape evolutionary trajectories in ΦX174.Virus evolution · 2026Article
- Characterizations of Newly IsolatedViruses · 2025Article
- Bacteriophage therapy for multidrug-resistant infections: current technologies and therapeutic approaches.The Journal of clinical investigation · 2025Review
- Review
- Article
- Phage Display Technology in Biomarker Identification with Emphasis on Non-Cancerous Diseases.Molecules (Basel, Switzerland) · 2024Review
- Group Selection as a Basis for Screening Mutagenized Libraries of Public Goods (Bacillus thuringiensis Cry Toxins).Applied and environmental microbiology · 2023Article
- Isolation and characterization of a novel phage belonging to a new genus against Vibrio parahaemolyticus.Virology journal · 2023Article
- Phage engineering and phage-assisted CRISPR-Cas delivery to combat multidrug-resistant pathogens.Bioengineering & translational medicine · 2023Review
- How to Tackle Bacteriophages: The Review of Approaches with Mechanistic Insight.International journal of molecular sciences · 2023Review
- Article
- Genomic Analysis Unveils the Pervasiveness and Diversity of Prophages InfectingPathogens (Basel, Switzerland) · 2022Article
- Isolation and Characterization of the LyticViruses · 2022Article
- Isolation and Characterization of a NovelViruses · 2022Article
- Review
- Role of Phage Capsid in the Resistance to UV-C Radiations.International journal of molecular sciences · 2021Article
- ComprehensiveMicrobial genomics · 2021Article
- Development of Antimicrobial Phototreatment Tolerance: Why the Methodology Matters.International journal of molecular sciences · 2021Review
- Application of Adaptive Evolution to Improve the Stability of Bacteriophages during Storage.Viruses · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The dsDNA bacteriophage T7 was subjected to 30 cycles of lethal ultraviolet light (UV) exposure to select increased resistance to UV. The exposure effected a 0.9999 kill of the ancestral population, and survival of the ending population was nearly 50-fold improved. At the end point, a 2.1 kb deletion of early genes and three substitutions in structural-genes were the only changes observed at high frequency throughout the 40 kb genome; no changes were observed in genes affecting DNA metabolism. The deletion accounted for only a two-fold improvement in survival. One possible explanation of its benefit is that it represents an error catastrophe, whereby the genome experiences a reduced mutation rate. The mechanism of benefit provided by the three structural-gene mutations remains unknown. The results offer some hope of artificially evolving greater protection against sunlight damage in applications of phage therapy to plants, but the response of T7 is weak compared to that observed in bacteria selected to resist ionizing radiation. Because of the weak response, mathematical analysis of the selection process was performed to determine how the protocol might have been modified to achieve a greater response, but the greatest protection may well come from evolving phages to bind materials that block the UV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.