ArticleGastroenterology and hepatology from bed to bench2018
Celiac disease microarray analysis based on System Biology Approach.
Article in Gastroenterology and hepatology from bed to bench, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Down-regulation of TP53 is a highlighted molecular event in gastric ulcer.Gastroenterology and hepatology from bed to bench · 2022Article
- Evaluation of expression of common genes in the intestine and peripheral blood mononuclear cells (PBMC) associated with celiac disease.Gastroenterology and hepatology from bed to bench · 2020Article
- Article
- Comparison of cytokine and gene activities in tissue and blood samples of patients with celiac disease.Gastroenterology and hepatology from bed to bench · 2019Article
- Effects of high fat medium conditions on cellular gene expression profile: a network analysis approach.Gastroenterology and hepatology from bed to bench · 2019Article
- Highlighted role of VEGFA in follow up of celiac disease.Gastroenterology and hepatology from bed to bench · 2019Article
- Evaluation of Skin Response After Erbium:Yttrium- Aluminum-Garnet Laser Irradiation: A Network Analysis Approach.Journal of lasers in medical sciences · 2019Article
- Dissecting the Role of NF-κb Protein Family and Its Regulators in Rheumatoid Arthritis Using Weighted Gene Co-Expression Network.Frontiers in genetics · 2019Article
- Structural and Functional Analysis of Crucial Protein Complex in Basal Cell Skin Carcinoma via Network Construction.Galen medical journal · 2018Article
- Comparative Bioinformatics Characteristic of Bladder Cancer Stage 2 from Stage 4 Expression Profile: A Network-Based Study.Galen medical journal · 2018Article
- Introducing Critical Pain-related Genes: A System Biology Approach.Basic and clinical neuroscienceArticle
- Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development.Basic and clinical neuroscienceArticle
- Introducing Genes With Significant Role in Migraine: An Interactomic Approach.Basic and clinical neuroscienceArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimAim of this study is screen of the large numbers of related genes of CD to find the key ones.
backgroundCeliac disease (CD) is known as a gluten sensitive and immune system dependent disease. There are several high throughput investigations about CD but it is necessary to clarify new molecular aspects mechanism of celiac.
methodsWhole-genome profile (RNA) of the human peripheral blood mononuclear cells (PBMCs) as Gene expression profile GSE113469 was retrieved Gene Expression Omnibus (GEO) database. The significant genes were selected and analyzed via protein-protein interaction (PPI) network by Cytoscape software. The key genes were introduced and enriched via ClueGO to find the related biochemical pathways.
resultsAmong 250 significant genes 47 genes with expressed change above 2 fold change (FC) were interacted and the constructed network were analyzed. The network characterized by poor connections so it was promoted by addition 50 related nodes and 18 crucial nodes were introduced. Two clusters of biochemical pathways were identified and discussed.
conclusionThere is an obvious conflict between microarray finding and the well-known related genes of CD. This problem can be solve by more attention to the interpretation of PPI ntwork analysis results.
Indexed as
Identifiers
30013745PMC6040039What OpenQuestion holds
Registered trials
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