ReviewGastroenterology and hepatology from bed to bench2018
The serological diagnosis of coeliac disease - a step forward.
Review in Gastroenterology and hepatology from bed to bench, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Defining the optimum strategy for identifying adults and children with coeliac disease: systematic review and economic modelling.Health technology assessment (Winchester, England) · 2022Pooled it
- Article
- Patterns of practice in the diagnosis, dietary counselling and follow-up of patients with celiac disease- A patient-based survey.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Article
- No-biopsy approach to the diagnosis of coeliac disease.Frontline gastroenterology · 2023Article
- No-biopsy strategy for coeliac disease is applicable in adult patients: a 'real-world' Scottish experience.Frontline gastroenterology · 2023Article
- No-biopsy diagnostic approach to coeliac disease.Gastroenterology and hepatology from bed to bench · 2023Review
- Upper gastrointestinal endoscopic findings in celiac disease at diagnosis: A multicenter international retrospective study.World journal of gastroenterology · 2022Observational
- Diagnosis of coeliac disease by flow cytometry of intraepithelial lymphocytes: a new 'gold' standard?Frontline gastroenterology · 2022Article
- Diagnosing coeliac disease in the elderly: a United Kingdom cohort study.Gastroenterology and hepatology from bed to bench · 2020Article
- Article
- The serological diagnosis of adult coeliac disease - a cautious step forward?Gastroenterology and hepatology from bed to bench · 2018Article
- Seronegative coeliac disease: Are they coeliac? When biopsy in adult can be avoided?Gastroenterology and hepatology from bed to bench · 2018Article
- Beyond biopsy: evaluating noninvasive techniques to diagnose celiac disease in adults.Annals of gastroenterologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of highly performing serological tests to identify patients with coeliac disease (CD), allowed large scale screening studies to be carried out and the results transformed our understanding of the prevalence of the condition in the general population. The next logical step was to ask whether CD could be reliably diagnosed by these tests without the need for small intestinal biopsies. This was shown to be the case. Studies from Derby, UK, indicated that about half of adult patients can be diagnosed in this way and similar figures have been provided for children. When considering this approach, it is essential that laboratories only use highly performing test kits that they have validated to measure tissue transglutaminase antibodies because all kits do not function to the same high standard. There remains a place for biopsy when criteria for serological diagnosis are not met, if the diagnosis of CD is strongly suspected but serological tests are negative or in patients not showing the expected responses to gluten free diet or otherwise causing concern, when not only small bowel biopsy will be indicated but also other investigations. Those with refractory CD should not be compromised by this diagnostic strategy. As serological tests become more refined and information accumulates, it is likely that this mode of diagnosis will gather momentum for the benefit of patients and carers. This brief review looks at the evidence for making the diagnosis of CD in some cases by serological tests alone.
Indexed as
Identifiers
30013744PMC6040038W2866447674What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.