Evidence map›Paper›PMID 30013570›Full record

ArticleFrontiers in immunology2018

Evaluating the Vaccine Potential of a Tetravalent Fusion Protein (

Nikhil Chauhan, Vishal Khatri, Priyankana Banerjee, Ramaswamy Kalyanasundaram

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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  10. Highlighting the Relevance of CD8Frontiers in immunology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nikhil ChauhanDepartment of Biomedical Sciences, University of Illinois, Rockford, IL, United States.
Vishal KhatriDepartment of Biomedical Sciences, University of Illinois, Rockford, IL, United States.
Priyankana BanerjeeDepartment of Biomedical Sciences, University of Illinois, Rockford, IL, United States.
Ramaswamy KalyanasundaramDepartment of Biomedical Sciences, University of Illinois, Rockford, IL, United States.
University of Illinois Chicago, Rockford campus · US

Funding

Identification and characterization of cellular factors involved in HCV entryR01AI072613 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2007 to 2016
$4.7M
NIAID NIH HHS R01 AI072613
6 · The paper itself

Abstract

Lymphatic filariasis (LF) is a tropical parasitic infection of human transmitted by mosquitoes. Chronic infection results in severe physical disability in the infected patients. Although several potential vaccine antigens were identified by several groups, there are no licensed prophylactic vaccine to date against this infection in the human. Previous attempts from our laboratory to develop a trivalent prophylactic vaccine against LF showed that >90% protection could be achieved in rodent models. However, this trivalent vaccine gave only 35% protection in non-human primates. The major focus of this study was to develop a tetravalent prophylactic vaccine (r

Indexed as

aluminumlymphatic filariasismouse modelmultivalent antigenprophylactic vaccineTLR-4

Identifiers

PMID30013570
PMCPMC6036175
OpenAlexW2809069164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.