ReviewFrontiers in immunology2018
Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.
Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
159 citing papers in PubMed, 6 syntheses or guidelines pooled it, 257 citations in OpenAlex.
- [Frailty in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Pooled it
- Prognostic value of the prognostic nutritional index in sepsis, pneumonia, and tuberculosis: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Risk factors, biomarkers, and mechanisms for persistent inflammation, immunosuppression, and catabolism syndrome (PICS): a systematic review and meta-analysis.British journal of anaesthesia · 2024Pooled it
- Administration of vitamin D and its metabolites in critically ill adult patients: an updated systematic review with meta-analysis of randomized controlled trials.Critical care (London, England) · 2022Pooled it
- Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis.Intensive care medicine · 2021Pooled it
- Potential Targets to Mitigate Trauma- or Sepsis-Induced Immune Suppression.Frontiers in immunology · 2021Pooled it
- Persistent inflammation, immunosuppression, and catabolism syndrome: from conceptual framework to biological endotype.Intensive care medicine · 2026Article
- Temporal Discordance of the Inflammation, Catabolism and Immunosuppression Triad in Chronic Critical Illness.Medicina (Kaunas, Lithuania) · 2026Article
- Article
- Functional immune changes are conserved in COVID-19 and trauma patients receiving intensive care.Nature communications · 2026Article
- Timing of disseminated intravascular coagulation onset is associated with development of persistent inflammation, immunosuppression, and catabolism syndrome in critically ill patients.Thrombosis journal · 2026Article
- Experimental sepsis causes SERCA2 expression in white adipose tissue but not classical browning.Scientific reports · 2026Article
- Host-directed immune therapies: a second front in the battle against sepsis.The Journal of clinical investigation · 2026Review
- Development and Validation of a Nomogram for Mortality Prediction in Septic Patients with Prolonged or Chronic Critical Illness.Diagnostics (Basel, Switzerland) · 2026Article
- Time course of energy expenditure in persistent critical illness: a prospective multicentre study.Critical care (London, England) · 2026Observational
- The Dual Role of Interleukin-10 in Sepsis: Research Progress and Therapeutic Prospects.Inflammation · 2026Review
- The clinical significance of myeloid-derived suppressor cells in patients with sepsis: a prospective cohort study.Scientific reports · 2026Observational
- Myeloid-derived suppressor cells in sepsis: drivers of persistent immunosuppression and targets for precision immunotherapy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Docosahexaenoic acid supplementation inhibits monocyte exhaustion memory formation during sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Comparative prognostic value of nutrition-inflammation indices for 1-year mortality in elderly intensive care unit patients: a retrospective observational study based on MIMIC-IV database.BMC geriatrics · 2026Observational
99 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Dysregulated host immune responses to infection often occur, leading to sepsis, multiple organ failure, and death. Some patients rapidly recover from sepsis, but many develop chronic critical illness (CCI), a debilitating condition that impacts functional outcomes and long-term survival. The "
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.