Evidence map›Paper›PMID 30013553›Full record

ArticleFrontiers in immunology2018

Lorinda Turner, Natalie J Bitto, David L Steer, Camden Lo, Kimberley D'Costa, Georg Ramm, Mitch Shambrook, Andrew F Hill, Richard L Ferrero, Maria Kaparakis-Liaskos

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 194 citations in OpenAlex.

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  17. Article
  18. Cytoplasmic membrane vesicles fromFrontiers in microbiology · 2026
    Article
  19. Outer membrane vesicles inMicrobial cell (Graz, Austria) · 2026
    Article
  20. Characterization ofFrontiers in microbiology · 2026
    Article

77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lorinda TurnerCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Melbourne, VIC, Australia.
Natalie J BittoDepartment of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne, VIC, Australia.
David L SteerMonash University, Clayton, VIC, Australia.
Camden LoMonash Micro Imaging, Monash University, Clayton, VIC, Australia.
Kimberley D'CostaCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Melbourne, VIC, Australia.
Georg RammMonash Biomedical Proteomics Facility, Monash University, Clayton, VIC, Australia.
Mitch ShambrookResearch Centre for Extracellular Vesicles, School of Molecular Sciences, La Trobe University, Melbourne, VIC, Australia.
Andrew F HillResearch Centre for Extracellular Vesicles, School of Molecular Sciences, La Trobe University, Melbourne, VIC, Australia.
Richard L FerreroCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Melbourne, VIC, Australia.
Maria Kaparakis-LiaskosCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Melbourne, VIC, Australia.
Monash University · AUHudson Institute of Medical Research · AULa Trobe University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gram-negative pathogens ubiquitously shed outer membrane vesicles (OMVs) that play a central role in initiating and regulating pathogenesis in the host. Due to their highly inflammatory nature, OMVs are extensively being examined for their role in mediating disease in addition to their applications in innovative vaccines. A key mechanism whereby OMVs mediate inflammation and disease progression is dependent on their ability to enter host cells. Currently, the role of OMV size on determining their mechanism of cellular entry and their protein composition remains unknown. In this study, we examined the mechanisms whereby OMV size regulates their mode of entry into epithelial cells, in addition to their protein cargo and composition. We identified that a heterogeneous sized population of

Indexed as

bacterial membrane vesiclesendocytosismacropinocytosisouter membrane vesiclespathogenesisproteomicssize

Identifiers

PMID30013553
PMCPMC6036113
OpenAlexW2810381319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.