Evidence map›Paper›PMID 30013542›Full record

ArticleFrontiers in microbiology2018

Human Endogenous Retrovirus K in the Crosstalk Between Cancer Cells Microenvironment and Plasticity: A New Perspective for Combination Therapy.

Emanuela Balestrieri, Ayele Argaw-Denboba, Alessandra Gambacurta, Chiara Cipriani, Roberto Bei, Annalucia Serafino, Paola Sinibaldi-Vallebona, Claudia Matteucci

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

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  13. Transcription from a gene desert in a melanoma porcine model.Molecular genetics and genomics : MGG · 2020
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  14. How do I see the production of engineered blood cells available for transfusion?Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Emanuela BalestrieriDepartment of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
Ayele Argaw-DenbobaDepartment of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
Alessandra GambacurtaDepartment of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
Chiara CiprianiDepartment of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
Roberto BeiDepartment of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.
Annalucia SerafinoInstitute of Translational Pharmacology, National Research Council, Rome, Italy.
Paola Sinibaldi-VallebonaDepartment of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
Claudia MatteucciDepartment of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
University of Rome Tor Vergata · ITIstituto di Farmacologia Traslazionale · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal activation of human endogenous retroviruses (HERVs) has been associated with several diseases such as cancer, autoimmunity, and neurological disorders. In particular, in cancer HERV activity and expression have been specifically associated with tumor aggressiveness and patient outcomes. Cancer cell aggressiveness is intimately linked to the acquisition of peculiar plasticity and heterogeneity based on cell stemness features, as well as on the crosstalk between cancer cells and the microenvironment. The latter is a driving factor in the acquisition of aggressive phenotypes, associated with metastasis and resistance to conventional cancer therapies. Remarkably, in different cell types and stages of development, HERV expression is mainly regulated by epigenetic mechanisms and is subjected to a very precise temporal and spatial regulation according to the surrounding microenvironment. Focusing on our research experience with HERV-K involvement in the aggressiveness and plasticity of melanoma cells, this perspective aims to highlight the role of HERV-K in the crosstalk between cancer cells and the tumor microenvironment. The implications for a combination therapy targeted at HERVs with standard approaches are discussed.

Indexed as

cancer biomarkercancer plasticitycancer therapycombination therapyendogenous retrovirusesreprogrammingstemnesstumor microenvironment

Identifiers

PMID30013542
PMCPMC6036167
OpenAlexW2810275248

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.