Evidence map›Paper›PMID 30013458›Full record

ArticleDose-response : a publication of International Hormesis Society

Recovery From Rheumatoid Arthritis Following 15 Months of Therapy With Low Doses of Ionizing Radiation: A Case Report.

Shuji Kojima, Mitsutoshi Thukimoto, Jerry M Cuttler, Kiyomi Inoguchi, Takahiro Ootaki, Noriko Shimura, Hironobu Koga, Akihisa Murata

Abstract readCase Reports
In one paragraph

Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Enzymatic Responses to Low-Intensity Radiation of Tritium.International journal of molecular sciences · 2020
    Article
  6. Article
  7. Death of the ALARA Radiation Protection Principle as Used in the Medical Sector.Dose-response : a publication of International Hormesis Society
    Article
  8. Review
  9. 5 Reasons Why Scoliosis X-Rays Are Not Harmful.Dose-response : a publication of International Hormesis Society
    Article
  10. Radon Therapy for Autoimmune Diseases Pemphigus and Diabetes: 2 Case Reports.Dose-response : a publication of International Hormesis Society
    Article
  11. Article
  12. Review
  13. Article
  14. Application of Low Doses of Ionizing Radiation in Medical Therapies.Dose-response : a publication of International Hormesis Society
    Article
  15. Article
  16. Radiophobia Harm, Its Main Cause, and a Proposed Solution.Dose-response : a publication of International Hormesis Society
    Article
  17. Necrotizing Fasciitis: Low-Dose Radiotherapy as a Potential Adjunct Treatment.Dose-response : a publication of International Hormesis Society
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuji KojimaDepartment of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science (TUS), Noda-shi, Chiba, Japan.
Mitsutoshi ThukimotoDepartment of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science (TUS), Noda-shi, Chiba, Japan.
Jerry M CuttlerCuttler and Associates Inc, Vaughan, Ontario, Canada.
Kiyomi InoguchiDrainage Co, Ltd, Minoo-shi, Osaka, Japan.
Takahiro OotakiOotaki Clinic, Toshima-ku, Osaka, Japan.
Noriko ShimuraFaculty of Pharmaceutical Sciences, Ohu University, Koriyama, Japan.
Hironobu KogaLead and Company Co, Ltd, Minami-ku, Yokohama, Japan.
Akihisa MurataLead and Company Co, Ltd, Minami-ku, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that occurs commonly in old people. Hot spring radon therapy is widely practiced in Central Europe and Japan for relief from the painful symptoms. The usual duration of a spa treatment is a week or two, and the relief is temporary. This article reports on the near-complete recovery of a patient who had been suffering from RA for 10 years. The patient received 15 months of low-dose radon and γ-radiation therapy in a room that reproduced the conditions of a radon spa. The daily 40-minute exposure in the therapy room was supplemented by ten 6-minute radio-nebulizer treatments. The inflammation markers C-reactive protein and matrix metalloproteinase 3 declined strongly to the normal level of 0.07 mg/dL and the near-normal level of 48.9 ng/mL, respectively. After the patient's return to good health, the frequency of the visits was reduced to twice each month. The patient's protection systems appear to have adapted to stimulated conditions, sufficiently to sustain the recovery from RA. Such a long-term course of treatments and follow-up maintenance could be carried out in any hospital that has these low-dose radiation therapy rooms. The therapy could be scheduled to suit patient availability.

Indexed as

hormesisimmune cellslow-dose radiationradon therapy roomrheumatoid arthritisTreg cells

Identifiers

PMID30013458
PMCPMC6043934

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.