ArticleReproductive medicine and biology2018
Effectiveness of high-dose transvaginal progesterone supplementation for women who are undergoing a frozen-thawed embryo transfer.
Article in Reproductive medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Preparation of the Endometrium for Frozen Embryo Transfer: A Systematic Review.Frontiers in endocrinology · 2021Pooled it
- Effects of vaginal vs oral progesterone supplementation before embryo transfer on live birth rates and levels: a randomized trial.Reproduction & fertility · 2025Trial
- A randomised control trial on oral dydrogesteroneJournal of medicine and life · 2023Trial
- Serum progesterone and vaginal gel dose in artificial-cycle frozen embryo transfer: association with pregnancy outcome.Frontiers in endocrinology · 2026Article
- Evaluation of two luteal support regimens, intramuscular progesterone and progesterone vaginal gel, for vitrified-warmed embryo transfer in women with chronic salpingitis: a single-center 8-year retrospective study.European journal of medical research · 2024Article
- Finding of the optimal preparation and timing of endometrium in frozen-thawed embryo transfer: a literature review of clinical evidence.Frontiers in endocrinology · 2023Review
- Article
- Clinical outcome of intrauterine infusion of platelet-rich plasma in patients with recurrent implantation failure.Reproductive medicine and biology · 2022Article
- Negative impact of high doses of follicle-stimulating hormone during superovulation on the ovulatory follicle function in small ovarian reserve dairy heifers†.Biology of reproduction · 2021Article
- Relationship between serum progesterone (P) levels and pregnancy outcome: lessons from artificial cycles when using vaginal natural micronized progesterone.Journal of assisted reproduction and genetics · 2020Article
- Predictive factors influencing pregnancy rate in frozen embryo transfer.Reproductive medicine and biology · 2020Article
- Efficacy of four vaginal progesterones for luteal phase support in frozen-thawed embryo transfer cycles: A randomized clinical trial.Reproductive medicine and biology · 2020Article
- Effects of intramuscular and vaginal progesterone supplementation on frozen-thawed embryo transfer.Scientific reports · 2019Article
- Effectiveness of high-dose transvaginal progesterone supplementation for women who are undergoing a frozen-thawed embryo transfer.Reproductive medicine and biology · 2018Article
- Authors' Response to the Commentary on "Micronized Vaginal Progesterone Dose and Serum Progesterone Thresholds Determine Reproductive Outcomes in Frozen-Thawed Embryo Transfer With Hormone Replacement Therapy".Reproductive medicine and biologyArticle
- Micronized Vaginal Progesterone Dose and Serum Progesterone Thresholds Determine Reproductive Outcomes in Frozen-Thawed Embryo Transfer With Hormone Replacement Therapy.Reproductive medicine and biologyArticle
- Differences in clinical outcomes between men with mosaic Klinefelter syndrome and those with non-mosaic Klinefelter syndrome.Reproductive medicine and biologyArticle
- The addition of dydrogesterone improves the outcomes of pregnant women with low progesterone levels when receiving vaginal progesterone alone as luteal support in HRT-FET cycles.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the effectiveness of high-dose progesterone supplementation for women who are undergoing a frozen-thawed embryo transfer (FET).
methodsAmong the 2010 FET cycles that were included in the present study, 1188 were 1200 mg/d of vaginal progesterone, while 822 were 900 mg/d. The dose of progesterone that was used was decided by the treatment period and additional progesterone supplementation was used when the serum progesterone levels were <9 ng/mL on luteal day 5.
resultsThe clinical pregnancy rate was higher in the 1200 mg group than in the 900 mg group. The mean serum progesterone level on luteal day 5 in the 1200 mg and 900 mg groups was 12.6 ng/mL and 13.4 ng/mL, respectively. The rate of additional progesterone supplementation was higher in the 1200 mg group. A logistic regression analysis identified a younger age (≤37 years) and the use of 1200 mg progesterone as independent predictive factors for the clinical pregnancy outcome. The analysis of the infant outcomes revealed no significant difference in the distribution of birth ages and weights.
conclusionHigh-dose transvaginal progesterone of 1200 mg/d as luteal support contributed to good pregnancy outcomes.
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Registered trials
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