Evidence map›Paper›PMID 30013387›Full record

ArticleJournal of experimental neuroscience2018

Homeostatic Regulation of Interneuron Apoptosis During Cortical Development.

Myrto Denaxa, Guilherme Neves, Juan Burrone, Vassilis Pachnis

Open access · goldAbstract read
In one paragraph

Article in Journal of experimental neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Myrto DenaxaDevelopment and Function of Cortical Interneurons Lab, BSRC Al. Fleming, Athens, Greece.ORCID https://orcid.org/0000-0003-0707-2616
Guilherme NevesCentre for Developmental Neurobiology, King's College London, London, UK.
Juan BurroneCentre for Developmental Neurobiology, King's College London, London, UK.
Vassilis PachnisDevelopment and Homeostasis of the Nervous System Laboratory, The Francis Crick Institute, London, UK.
King's College London · GBAlexander Fleming Biomedical Sciences Research Center · GRThe Francis Crick Institute · GB

Funding

Medical Research Council MR/N026063/1Wellcome Trust
6 · The paper itself

Abstract

The mammalian cortex consists of two main neuronal types: the principal excitatory pyramidal neurons (PNs) and the inhibitory interneurons (INs). The interplay between these two neuronal populations - which drive excitation and inhibition (E/I balance), respectively - is crucial for controlling the overall activity in the brain. A number of neurological and psychiatric disorders have been associated with changes in E/I balance. It is not surprising, therefore, that neural networks employ several different mechanisms to maintain their firing rates at a stable level, collectively referred as homeostatic forms of plasticity. Here, we share our views on how the size of IN populations may provide an early homeostatic checkpoint for controlling brain activity. In a recent paper published in

Indexed as

cell deathCortical interneuronsLhx6 transcription factorneuronal activity

Identifiers

PMID30013387
PMCPMC6043931
OpenAlexW2848844646

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.