Evidence map›Paper›PMID 30013346›Full record

ArticleInternational journal of nanomedicine2018

Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery.

Henry M Smilowitz, Alexandria Meyers, Khalil Rahman, Nathaniel A Dyment, Dan Sasso, Crystal Xue, Douglas L Oliver, Alexander Lichtler, Xiaomeng Deng, Sharif M Ridwan and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Henry M SmilowitzDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT, smilowitz@uchc.edu.
Alexandria MeyersDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT, smilowitz@uchc.edu.
Khalil RahmanDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT, smilowitz@uchc.edu.
Nathaniel A DymentDepartment of Orthopedic Surgery, University of Pennsylvania, Philadelphia, PA.
Dan SassoDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT, smilowitz@uchc.edu.
Crystal XueGeorge Washington University School of Medicine, Washington, DC.
Douglas L OliverDepartment of Neuroscience, University of Connecticut Health Center, Farmington, CT.
Alexander LichtlerDepartment of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT.
Xiaomeng DengDavid Geffen School of Medicine at UCLA, Student Affairs Office, Los Angeles, CA.
Sharif M RidwanDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT, smilowitz@uchc.edu.
Lauren J TarmuDepartment of Human Behavior, College of Southern Nevada.
Qian WuDepartment of Anatomic Pathology, University of Connecticut Health Center, Farmington.
Andrew L SalnerThe Gray Cancer Center, Hartford Hospital, Hartford.
Ketan R BulsaraDivision of Neurosurgery, UConn Health, Farmington, CT.
Daniel N SlatkinNanoprobes, Inc, Yaphank, NY, USA.
James F HainfeldNanoprobes, Inc, Yaphank, NY, USA.
UConn Health · USNanoprobes (United States) · USCollege of Southern Nevada · USGeorge Washington University · USHartford Hospital · USUniversity of California, Los Angeles · USUniversity of Pennsylvania · US

Funding

Gold Nanoparticle Treatment of GliomaR43CA192702 · NCI · NANOPROBES, INC. · PI HAINFELD, JAMES F · 2016 to 2016
$246k
NCI NIH HHS R43 CA192702
6 · The paper itself

Abstract

backgroundIntravenously (IV)-injected gold nanoparticles (AuNPs) powerfully enhance the efficacy of X-ray therapy of tumors including advanced gliomas. However, pharmacokinetic issues, such as slow tissue clearance and skin discoloration, may impede clinical translation. The direct infusion of AuNPs into the tumor might be an alternative mode of delivery. MATERIALS AND

methodsUsing the advanced, invasive, and difficult-to-treat F98 rat glioma model, we have studied the biodistribution of the AuNPs in the tumor and surrounding brain after either IV injection or direct intratumoral infusion by convection-enhanced delivery using light microscopy immunofluorescence and direct gold visualization.

resultsIV-injected AuNPs localize more specifically to intracerebral tumor cells, both in the main tumor mass and in the migrated tumor cells as well as the tumor edema, than do the directly infused AuNPs. Although some of the directly infused AuNPs do access the main tumor region, such access is largely restricted.

conclusionThese data suggest that IV-injected AuNPs are likely to have a greater therapeutic benefit when combined with radiation therapy than after the direct infusion of AuNPs.

Indexed as

ConvectionDrug Delivery SystemsAnimalsAstrocytesBrain NeoplasmsCell Line, TumorEdemaGliomaGoldInjections, IntravenousMetal NanoparticlesMicrogliaNeoplasm InvasivenessRatsRats, Inbred F344Stereotaxic TechniquesGoldconvection-enhanced deliveryedemafluorescence microscopygliomagold enhancegold nanoparticlesIV injection

Identifiers

PMID30013346
PMCPMC6038872
OpenAlexW2810105253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.