ArticleDrug design, development and therapy2018
The possibility of healing alveolar bone defects with simvastatin thermosensitive gel: in vitro/in vivo evaluation.
Article in Drug design, development and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Statins-Their Role in Bone Tissue Metabolism and Local Applications with Different Carriers.International journal of molecular sciences · 2024Review
- Thermosensitive In Situ Gels for Joint Disorders: Pharmaceutical Considerations in Intra-Articular Delivery.Gels (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
backgroundIn this study, simvastatin (SVT) in situ gels were successfully produced by our group.
methodsThe preparations were characterized in the following aspects: in vitro gelation, drug release, stability and pharmacodynamics.
resultsIn this study, drug content of prepared gels was found to be in the range between 89 and 92%. The pH value was in the range between 6.5 and 7.0. The gelation temperature of the prepared thermogelling solutions was 37°C. In vitro release showed that the release of SVT from in situ gels was slow with burst effects at an early stage. Researches indicated that intraorally slow release SVT in situ gels could effectively promote bone regeneration repair of alveolar bone defect.
conclusionThis drug delivery system could prove to be a novel form able to prolong the residence time and to control the release of drug when administered into the oral cavity.
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