Evidence map›Paper›PMID 30013310›Full record

ArticleDrug target insights2018

Valacyclovir Neurotoxicity and Nephrotoxicity in an Elderly Patient Complicated by Hyponatremia.

Takuya Murakami, Tetsu Akimoto, Mari Okada, Erika Hishida, Taro Sugase, Atsushi Miki, Marina Kohara, Hiromichi Yoshizawa, Takahiro Masuda, Takahisa Kobayashi and 3 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug target insights, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Takuya MurakamiDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
Tetsu AkimotoDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
Mari OkadaDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
Erika HishidaDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
Taro SugaseDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
Atsushi MikiDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
Marina KoharaDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
Hiromichi YoshizawaDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
Takahiro MasudaDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
Takahisa KobayashiDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
Osamu SaitoDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
Shigeaki MutoDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
Daisuke NagataDivision of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.
Jichi Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 66-year-old women with no history of renal disease was admitted due to a coma and acute kidney injury with a serum creatinine level of 7.44 mg/dL which were ascribed to valacyclovir neurotoxicity and nephrotoxicity, respectively. She had received valacyclovir at a standard dosage for the treatment of herpes zoster and was finally discharged, having fully returned to her normal baseline mental status with a recovered serum creatinine level of 0.68 mg/dL. We feel that awareness of this pathology remains a challenge for physicians and therefore strongly recommend the further accumulation of experiences similar to our own. Our experience underscores the pitfalls of administering valacyclovir to elderly patients who barely appear to have a favorable renal function. Several concerns regarding the therapeutic management, including blood purification strategies, that emerged in this case are also discussed.

Indexed as

acute kidney injuryhemodialysishyponatremiaosmotic demyelination syndromeValacyclovir neurotoxicity

Identifiers

PMID30013310
PMCPMC6043912
OpenAlexW2809994950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.