Evidence map›Paper›PMID 30013270›Full record

ArticleIndian journal of microbiology2018

New Insights on Cyclization Specificity of Fungal Type III Polyketide Synthase, PKSIII

Amreesh Parvez, Samir Giri, Renu Bisht, Priti Saxena

Abstract read
In one paragraph

Article in Indian journal of microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Amreesh Parvez *1Chemical Biology Group, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi, 110021 India.
Samir Giri *1Chemical Biology Group, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi, 110021 India.
Renu Bisht1Chemical Biology Group, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi, 110021 India.
Priti Saxena1Chemical Biology Group, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi, 110021 India.ORCID 0000-0002-5579-2071
South Asian University · INOsnabrück University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type III polyketide synthases (PKSs) biosynthesize varied classes of metabolites with diverse bio-functionalities. Inherent promiscuous substrate specificity, multiple elongations of reaction intermediates and several modes of ring-closure, confer the proteins with the ability to generate unique scaffolds from limited substrate pools. Structural studies have identified crucial amino acid residues that dictate type III PKS functioning, though cyclization specific residues need further investigation. PKSIII

Indexed as

Acyl-phloroglucinolAlkyl-resorcinolNeurospora crassaPKSIIINcType III polyketide synthase

Identifiers

PMID30013270
PMCPMC6023819
OpenAlexW2800678777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.