SynthesisNature genetics2018
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
Erratum issued Registry-linked trialOpen access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06523478 (A Study on the Efficacy and Safety of Intratonsillar Immunotherapy for Allergic Rhinitis), which is not on this map. Cited by 82 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 2 pooled it
9.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Study on the Efficacy and Safety of Intratonsillar Immunotherapy for Allergic Rhinitis
Who cites it
82 citing papers in PubMed, 2 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- Genetic characterization of preschool wheeze phenotypes.The Journal of allergy and clinical immunology · 2025Pooled it
- Genetic Variation and Hot Flashes: A Systematic Review.The Journal of clinical endocrinology and metabolism · 2020Pooled it
- Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age.The Journal of allergy and clinical immunology · 2020Trial
- Causal associations between plasma miRNAS and allergic rhinitis: A two-sample Mendelian randomization and functional enrichment study.Brazilian journal of otorhinolaryngology · 2026Article
- Dynamic CD4+ T Cell Genetics Identifies Candidate Therapeutic Targets for Allergic Rhinitis: Mendelian Randomization with Exploratory Single-Cell Contextualization.Biomedicines · 2026Article
- Role and mechanism of quercetin via the TLR4/MyD88/IRAK4 signaling pathway in the treatment of allergic rhinitis.Experimental and therapeutic medicine · 2026Article
- Multitrait analysis of genome-wide association studies expands eosinophilic esophagitis genetic susceptibility and polygenic risk scores.The Journal of allergy and clinical immunology · 2026Article
- Bidirectional association between immune-mediated diseases and major depressive disorder: evidence from cohort, genome-wide pleiotropic, and experimental studies.Molecular psychiatry · 2026Article
- Early life factors and genetic interactions in allergic rhinitis: a genome-wide study.BMC pediatrics · 2026Article
- Prediction of allergic disease trajectories from birth up to adolescence.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Interstitial cystitis: a phenotype and rare variant exome sequencing study.EBioMedicine · 2026Article
- The Immunogenetic Landscape of Allergic Rhinitis: from Cellular Effectors to Gene Regulation and Targeted Therapies.International journal of biological sciences · 2026Review
- Genetic associations and candidate functional genes linking depression and obesity: a multi-omics integrative study.Frontiers in genetics · 2026Article
- Genome-Wide Cross-Trait Analysis in European Populations Reveals Shared Genetic Architecture of Chronic Obstructive Pulmonary Disease and the Allergy Spectrum.International archives of allergy and immunology · 2025Article
- Use of bidirectional Mendelian randomization to unveil the association between antibody-mediated immune responses to infectious agents and allergic rhinitis.Human vaccines & immunotherapeutics · 2025Review
- Disentangling the comorbidity between allergic disease and type 1 diabetes using genetically informative designs.The journal of allergy and clinical immunology. Global · 2025Article
- Article
- DNA methylation of food sensitization in a French-Canadian population.Clinical epigenetics · 2025Article
- Association Between Peach and Olive Pollen Non-Specific Lipid Transfer Protein Allergy and HLA Class II Phenotype.International journal of molecular sciences · 2025Article
- Association of ZNF608 Polymorphisms With House Dust Mite-Induced Allergic Rhinitis.Clinical and translational allergy · 2025Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
90 authors at 20 institutions in 12 countries.
Johannes WaageCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Marie StandlInstitute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
John A CurtinDivision of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Leon E JessenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2879-2559
Jonathan ThorsenCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0200-0461
Chao Tian23andMe, Inc., Mountain View, CA, USA.
Nathan SchoettlerDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.
23andMe Research Team
AAGC collaborators
Carlos FloresResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Tenerife, Spain.ORCID http://orcid.org/0000-0001-5352-069X
Abdel AbdellaouiDepartment of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Tarunveer S AhluwaliaCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-7464-3354
Alexessander C AlvesDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.
Andre F S AmaralPopulation Health and Occupational Disease, National Heart and Lung Institute, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-0369-9449
Josep M AntóISGlobal, Barcelona, Spain.
Andreas ArnoldClinic and Polyclinic of Dermatology, University Medicine Greifswald, Greifswald, Germany.
Amalia Barreto-LuisResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Tenerife, Spain.
Hansjörg BaurechtDepartment of Dermatology, Venereology and Allergology, University-Hospital Schleswig-Hostein, Campus Kiel, Kiel, Germany.
Catharina E M van BeijsterveldtDepartment of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Eugene R BleeckerDivisions of Pharmacogenomics and Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
Sílvia Bonàs-GuarchBarcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona, Spain.
Dorret I BoomsmaDepartment of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Susanne BrixDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0001-8951-6705
Supinda BunyavanichDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-6108-439X
Esteban G BurchardDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Zhanghua ChenDepartment of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.
Ivan CurjuricUniversity of Basel, Basel, Switzerland.
Adnan CustovicDepartment of Paediatrics, Imperial College London, London, UK.
Herman T den DekkerThe Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.
Shyamali C DharmageAllergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Julia DmitrievaLaboratory of Animal Genomics, Unit of Medical Genomics, GIGA Institute, University of Liège, Liège, Belgium.
Liesbeth DuijtsThe Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.
Markus J EgeLMU Munich, Dr von Hauner Children's Hospital, Munich, and German Center for Lung Research (DZL), Munich, Germany.ORCID http://orcid.org/0000-0001-6643-3923
W James GaudermanDepartment of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.
Michel GeorgesLaboratory of Animal Genomics, Unit of Medical Genomics, GIGA Institute, University of Liège, Liège, Belgium.
Christian GiegerInstitute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Frank GillilandDepartment of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.
Raquel GranellMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Hongsheng GuiCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, MI, USA.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8748-3831
Joachim HeinrichInstitute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
John HendersonMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Natalia Hernandez-PachecoResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Tenerife, Spain.
Patrick HoltTelethon Kids Institute (TKI), Perth, Western Australia, Australia.
Medea ImbodenUniversity of Basel, Basel, Switzerland.
Vincent W V JaddoeThe Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.
Deborah L JarvisPopulation Health and Occupational Disease, National Heart and Lung Institute, Imperial College London, London, UK.
Kamilla K JensenDepartment of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0001-9217-7142
Ingileif JónsdóttirdeCODE genetics/Amgen Inc, Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-8339-150X
Michael KabeschDepartment of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
Jaakko KaprioDepartment of Public Health, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3716-2455
Ashish KumarUniversity of Basel, Basel, Switzerland.
Young-Ae LeeMax-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Albert M LevinDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA.
Xingnan LiDivisions of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
Fabian Lorenzo-DiazGenomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Tenerife, Spain.
Erik MelénInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Josep M MercaderBarcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona, Spain.ORCID http://orcid.org/0000-0001-8494-3660
Deborah A MeyersDivisions of Pharmacogenomics and Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
Rachel MyersDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.
Dan L NicolaeDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.
Ellen A NohrInstitute of Clinical Research, University of Southern Denmark, Department of Obstetrics & Gynecology, Odense University Hospital, Odense, Denmark.
Teemu PalviainenInstitute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-7847-8384
Lavinia PaternosterMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Craig E PennellSchool of Medicine and Public Health, Faculty of Medicine and Health, University of Newcastle, Callaghan, New South Wales, Australia.
Göran PershagenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Maria Pino-YanesResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Tenerife, Spain.ORCID http://orcid.org/0000-0003-0332-437X
Nicole M Probst-HenschUniversity of Basel, Basel, Switzerland.
Franz RüschendorfMax-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.ORCID http://orcid.org/0000-0001-5640-810X
Angela SimpsonDivision of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Kari StefanssondeCODE genetics/Amgen Inc, Reykjavik, Iceland.
Jordi SunyerISGlobal, Barcelona, Spain.
Gardar SveinbjornssondeCODE genetics/Amgen Inc, Reykjavik, Iceland.
Elisabeth ThieringInstitute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Philip J ThompsonInstitute for Respiratory Health, Harry Perkins Institute of Medical Research, University of Western Australia, Nedlands, Western Australia, Australia.
Maties TorrentIb-Salut, Area de Salut de Menorca, Institut d'Investigacio Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain.
David TorrentsBarcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona, Spain.
Joyce Y Tung23andMe, Inc., Mountain View, CA, USA.
Carol A WangSchool of Medicine and Public Health, Faculty of Medicine and Health, University of Newcastle, Callaghan, New South Wales, Australia.ORCID http://orcid.org/0000-0002-4301-3974
Stephan WeidingerDepartment of Dermatology, Venereology and Allergology, University-Hospital Schleswig-Hostein, Campus Kiel, Kiel, Germany.
Scott WeissChanning Division of Network Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7196-303X
Gonneke WillemsenDepartment of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
L Keoki WilliamsCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, MI, USA.
Carole OberDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.
David A Hinds23andMe, Inc., Mountain View, CA, USA.ORCID http://orcid.org/0000-0002-4911-803X
Manuel A FerreiraQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Hans BisgaardCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
David P StrachanPopulation Health Research Institute, St George's, University of London, London, UK.
Klaus BønnelykkeCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. kb@copsac.com.ORCID http://orcid.org/0000-0003-2003-1018
University of Copenhagen · DKUniversidad de La Laguna · ESdeCODE Genetics (Iceland) · ISUniversity of Southern California · USSwiss Tropical and Public Health Institute · CHUniversity of Arizona · USHenry Ford Health System · USUniversity of Helsinki · FIImperial College London · GBUniversity of Chicago · USUniversity of Liège · BEBarcelona Supercomputing Center · ESBrigham and Women's Hospital · USErasmus MC · NLHelmholtz Zentrum München · DEInstitució Catalana de Recerca i Estudis Avançats · ESThe University of Western Australia · AUUniversity Hospital Schleswig-Holstein · DE23andMe (United States) · USBarcelona Institute for Global Health · ES
Funding
Prenatal Origins of AsthmaR01HL129735 · NHLBI · UNIVERSITY OF CHICAGO · PI BISGAARD, HANS, OBER, CAROLE · 2015 to 2018
$3.2MDevelopment of a web-based database and research engine for genetic discoveryR44HG006981 · NHGRI · 23ANDME, INC. · PI MOUNTAIN, JOANNA L. · 2013 to 2014
$1.4MGenetics of Allergic Disease in a Participatory Research CohortR43HL115873 · NHLBI · 23ANDME, INC. · PI HINDS, DAVID ALAN · 2012 to 2012
$143kMedical Research Council G0601361Medical Research Council G9815508Medical Research Council MC_UU_12013/1Medical Research Council MR/J012165/1Medical Research Council MR/K002449/1NHGRI NIH HHS R44 HG006981NHLBI NIH HHS R01 HL129735NHLBI NIH HHS R43 HL115873
Abstract
Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries
Indexed as
AllergensCase-Control StudiesGenetic LociGenetic Predisposition to DiseaseGenetic VariationGenome, HumanGenome-Wide Association StudyHLA AntigensHumansPhenotypeRhinitis, AllergicRiskAllergensHLA Antigens
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT06523478ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.