Evidence map›Paper›PMID 30013097›Full record

ArticleNature communications2018

TCM visualizes trajectories and cell populations from single cell data.

Wuming Gong, Il-Youp Kwak, Naoko Koyano-Nakagawa, Wei Pan, Daniel J Garry

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wuming GongLillehei Heart Institute, University of Minnesota, 2231 6th St S.E, 4-165 CCRB, Minneapolis, MN, 55114, USA.ORCID http://orcid.org/0000-0002-3147-4028
Il-Youp KwakLillehei Heart Institute, University of Minnesota, 2231 6th St S.E, 4-165 CCRB, Minneapolis, MN, 55114, USA.
Naoko Koyano-NakagawaLillehei Heart Institute, University of Minnesota, 2231 6th St S.E, 4-165 CCRB, Minneapolis, MN, 55114, USA.
Wei PanDivision of Biostatistics, School of Public Health, University of Minnesota, 420 Delaware St. S.E., Mayo Bldg. A302, Minneapolis, MN, 55455, USA.
Daniel J GarryLillehei Heart Institute, University of Minnesota, 2231 6th St S.E, 4-165 CCRB, Minneapolis, MN, 55114, USA. garry@umn.edu.

Funding

Midwestern Progenitor Cell ConsortiumU01HL100407 · NHLBI · UNIVERSITY OF MINNESOTA · PI GARRY, DANIEL J., KYBA, MICHAEL · 2009 to 2015
$7.8M
Regulatory Mechanisms of Endothelial Development and RegenerationR01HL122576 · NHLBI · UNIVERSITY OF MINNESOTA · PI GARRY, DANIEL J. · 2014 to 2017
$1.5M
NHLBI NIH HHS R01 HL122576NHLBI NIH HHS U01 HL100407U.S. Department of Defense (DOD) GRANT11763537U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL122576
6 · The paper itself

Abstract

Profiling single cell gene expression data over specified time periods are increasingly applied to the study of complex developmental processes. Here, we describe a novel prototype-based dimension reduction method to visualize high throughput temporal expression data for single cell analyses. Our software preserves the global developmental trajectories over a specified time course, and it also identifies subpopulations of cells within each time point demonstrating superior visualization performance over six commonly used methods.

Indexed as

AlgorithmsGene Expression Regulation, DevelopmentalActivinsBone Morphogenetic Protein 4Cell DifferentiationFibroblast Growth Factor 2Gene Expression ProfilingHumansInduced Pluripotent Stem CellsMultifactor Dimensionality ReductionMyocytes, CardiacPyridinesPyrimidinesSingle-Cell AnalysisSoftwareactivin AActivinsBMP4 protein, humanBone Morphogenetic Protein 4Chir 99021Fibroblast Growth Factor 2PyridinesPyrimidines

Identifiers

PMID30013097
PMCPMC6048168

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.