Evidence map›Paper›PMID 30013095›Full record

ArticleScientific reports2018

A Novel Multi-Gene Detection Platform for the Analysis of miRNA Expression.

Chia-Hsun Hsieh, Wei-Ming Chen, Yi-Shan Hsieh, Ya-Chun Fan, Pok Eric Yang, Shih-Ting Kang, Chun-Ta Liao

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. microRNAs as Biomarkers of Breast Cancer.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chia-Hsun HsiehDivision of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Wei-Ming ChenDepartment of Application Development, Quark Biosciences, Inc., Zhubei City, Hsinchu, Taiwan.
Yi-Shan HsiehDepartment of Application Development, Quark Biosciences, Inc., Zhubei City, Hsinchu, Taiwan.
Ya-Chun FanDepartment of Application Development, Quark Biosciences, Inc., Zhubei City, Hsinchu, Taiwan.
Pok Eric YangDepartment of Application Development, Quark Biosciences, Inc., Zhubei City, Hsinchu, Taiwan.
Shih-Ting KangDepartment of Application Development, Quark Biosciences, Inc., Zhubei City, Hsinchu, Taiwan. benniekang@quarkbiosciences.com.
Chun-Ta LiaoDepartment of Otorhinolaryngology, Head & Neck Surgery, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan. liaoct@cgmh.org.tw.
Chang Gung Memorial Hospital · TWLinkou Chang Gung Memorial Hospital · TW

Funding

Chang Gung Memorial Hospital, Linkou (Linkou Chang Gung Memorial Hospital) CMRPG3D1063, CMRPG3D1073Chang Gung Memorial Hospital, Linkou (Linkou Chang Gung Memorial Hospital) CMRPG3E1633, CMRPG3E0512, and CMRPG3G0591-2Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 104-2314-B-182A-073-MY3
6 · The paper itself

Abstract

The study of miRNAs and their roles as non-invasive biomarkers has been intensely conducted in cancer diseases over the past decade. Various platforms, ranging from conventional qPCRs to Next Generation Sequencers (NGS), have been widely used to analyze miRNA expression. Here we introduced a novel platform, PanelChip™ Analysis System, which provides a sensitive solution for the analysis of miRNA levels in blood. After conducting miRQC analysis, the system's analytical performance compared favorably against similar nanoscale qPCR-based array technologies. Because PanelChip™ requires only a minimal amount of miRNA for analysis, we used it to screen for potential diagnostic biomarkers in the plasma of patients with oral cavity squamous cell carcinoma (OSCC). Combining the platform with a machine learning algorithm, we were able to discover miRNA expression patterns capable of separating healthy subjects from patients with OSCC.

Indexed as

AdultAgedBiomarkers, TumorCirculating MicroRNAFemaleGene Expression ProfilingHumansLiquid BiopsyMachine LearningMaleMiddle AgedMouth NeoplasmsOligonucleotide Array Sequence AnalysisReal-Time Polymerase Chain ReactionSensitivity and SpecificitySquamous Cell Carcinoma of Head and NeckBiomarkers, TumorCirculating MicroRNA

Identifiers

PMID30013095
PMCPMC6048151
OpenAlexW2834488773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.