ArticleScientific reports2018
The Roles of Serotonin in Decision-making under Social Group Conditions.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Social rank and social environment combinedly affect REM sleep in mice.Scientific reports · 2026Article
- Article
- A Multiparadigm Approach to Characterize Dominance Behaviors in CD1 and C57BL6 Male Mice.eNeuro · 2024Article
- Manifestations of domination: Assessments of social dominance in rodents.Genes, brain, and behavior · 2022Review
- In vitro monitoring of HTR2A-positive neurons derived from human-induced pluripotent stem cells.Scientific reports · 2021Article
- Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia.Translational psychiatry · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
People in a social group often have to make decisions under conflict, for instance, to conform to the group or obey authority (subjects at higher social rank in the group). The neural mechanisms underlying how social group setting affects decision-making have largely remained unclear. In this study, we designed novel behavioral tests using food access priority and fear conditioning paradigms that captured decision-making under conflict associated with social group environments in mice and examined the roles of serotonin (5-HT) on these processes. Using these behavioral tests, administration of the selective 5-HT reuptake inhibitor, which increased 5-HT transmission, was found to attenuate conflicts in decision-making that may be associated with human cases of social obedience and conformity in mice under group housing. The results suggest that 5-HT plays important roles in the regulation of individual behaviors that organize social group dynamics.
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Registered trials
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