ArticleScientific reports2018
Dentinogenic effects of extracted dentin matrix components digested with matrix metalloproteinases.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Stage-Specific Proteomic Profiles in Dental Caries.Journal of dental research · 2026Article
- The Role of Matrix Metalloproteinases in Orthodontics, Dental Trauma, Restorative Dentistry, and Endodontics: Molecular Mechanisms and Clinical Implications.International journal of molecular sciences · 2026Review
- Hemostatic efficacy of a novel Ca/P/S-based bone graft material and its preliminary clinical evidence in sternum closure procedures.Frontiers in bioengineering and biotechnology · 2026Article
- Review
- Resolvin D2-induced reparative dentin and pulp stem cells after pulpotomy in a rat model.Heliyon · 2024Article
- The Reparative Function of MMP13 in Tertiary Reactionary Dentinogenesis after Tooth Injury.International journal of molecular sciences · 2024Article
- Multivariate prognostic analysis of direct pulp capping using a bioceramic material in mature permanent teeth with carious pulp exposure: a retrospective cohort study.Clinical oral investigations · 2023Article
- Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials.Bioactive materials · 2023Article
- Dentin Degradation: From Tissue Breakdown to Possibilities for Therapeutic Intervention.Current oral health reports · 2023Article
- Novel Functional Peptide for Next-Generation Vital Pulp Therapy.Journal of dental research · 2023Article
- Treated Dentin Matrix in Tissue Regeneration: Recent Advances.Pharmaceutics · 2022Review
- Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects.International journal of molecular sciences · 2022Review
- Exploiting Dentine Matrix Proteins in Cell-Free Approaches for Periradicular Tissue Engineering.Tissue engineering. Part B, Reviews · 2022Review
- Dentin Matrix Metalloproteinases: A Futuristic Approach Toward Dentin Repair and Regeneration.Cureus · 2022Review
- Present status and future directions-Vital pulp treatment and pulp preservation strategies.International endodontic journal · 2022Review
- Extracellular Matrix in Human Craniofacial Development.Journal of dental research · 2022Review
- The Critical Role of MMP13 in Regulating Tooth Development and Reactionary Dentinogenesis Repair Through the Wnt Signaling Pathway.Frontiers in cell and developmental biology · 2022Article
- Dentine matrix metalloproteinases as potential mediators of dentine regeneration.European cells & materials · 2021Review
- Biomineralization of Dental Tissues Treated with Silver Diamine Fluoride.Journal of dental research · 2021Article
- Immunohistochemical study of dental pulp cells with 3D collagen type I gel in demineralized dentin tubules in vivo.Bosnian journal of basic medical sciences · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dentin is primarily composed of hydroxyapatite crystals within a rich organic matrix. The organic matrix comprises collagenous structural components, within which a variety of bioactive molecules are sequestered. During caries progression, dentin is degraded by acids and enzymes derived from various sources, which can release bioactive molecules with potential reparative activity towards the dentin-pulp complex. While these molecules' repair activities in other tissues are already known, their biological effects are unclear in relation to degradation events during disease in the dentin-pulp complex. This study was undertaken to investigate the effects of dentin matrix components (DMCs) that are partially digested by matrix metalloproteinases (MMPs) in vitro and in vivo during wound healing of the dentin-pulp complex. DMCs were initially isolated from healthy dentin and treated with recombinant MMPs. Subsequently, their effects on the behaviour of primary pulp cells were investigated in vitro and in vivo. Digested DMCs modulated a range of pulp cell functions in vitro. In addition, DMCs partially digested with MMP-20 stimulated tertiary dentin formation in vivo, which exhibited a more regular tubular structure than that induced by treatment with other MMPs. Our results indicate that MMP-20 may be especially effective in stimulating wound healing of the dentin-pulp complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.