ArticleScientific reports2018
A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Updated analysis to reject the laboratory-engineering hypothesis of SARS-CoV-2.Environmental research · 2023Article
- Animal Models of COVID-19: Nonhuman Primates.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets.Nature microbiology · 2021Article
- Article
- Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2.Infectious diseases of poverty · 2020Article
- Cell and animal models of SARS-CoV-2 pathogenesis and immunity.Disease models & mechanisms · 2020Review
- SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.Cell · 2020Article
- A Comprehensive Review of Animal Models for Coronaviruses: SARS-CoV-2, SARS-CoV, and MERS-CoV.Virologica Sinica · 2020Review
- Histopathologic Evaluation and Scoring of Viral Lung Infection.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome.Methods in molecular biology (Clifton, N.J.) · 2020Article
- The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose-only exposure device.Animal models and experimental medicine · 2019Article
- Epitope-based peptide vaccine design and target site depiction against Middle East Respiratory Syndrome Coronavirus: an immune-informatics study.Journal of translational medicine · 2019Article
- Middle East respiratory syndrome: pathogenesis and therapeutic developments.Future virology · 2019Review
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
The recurrence of new human cases of Middle East respiratory syndrome coronavirus (MERS-CoV) underscores the need for effective therapeutic countermeasures. Nonhuman primate models are considered the gold standard for preclinical evaluation of therapeutic countermeasures. However, MERS-CoV-induced severe respiratory disease in humans is associated with high viral loads in the lower respiratory tract, which may be difficult to achieve in nonhuman primate models. Considering this limitation, we wanted to ascertain the effectiveness of using a MERS-CoV infectious clone (icMERS-0) previously shown to replicate to higher titers than the wild-type EMC 2012 strain. We observed respiratory disease resulting from exposure to the icMERS-0 strain as measured by CT in rhesus monkeys with concomitant detection of virus antigen by immunohistochemistry. Overall, respiratory disease was mild and transient, resolving by day 30 post-infection. Although pulmonary disease was mild, these results demonstrate for the first time the utility of CT imaging to measure disease elicited by a MERS-CoV infectious clone system in nonhuman primate models.
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