ArticleHypertension (Dallas, Tex. : 1979)2018
Immunohistopathology and Steroid Profiles Associated With Biochemical Outcomes After Adrenalectomy for Unilateral Primary Aldosteronism.
Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Usefulness of steroid profiling in the diagnosis of primary Aldosteronism a systematic review.Endocrine · 2026Pooled it
- Identification of risk loci for primary aldosteronism in genome-wide association studies.Nature communications · 2022Pooled it
- From bench to bedside: primary aldosteronism revisited.Endocrine connections · 2026Article
- Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density-Dependent Mechanisms in Aldosterone-Producing Adenomas.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- An interpretable machine learning model for preoperative prediction of aldosterone secretion and CYP11B2 status of adrenal gland.BMC medical imaging · 2026Article
- Primary aldosteronism beyond laterality: integrating subtype assignment with outcome-oriented risk stratification.Frontiers in endocrinology · 2026Review
- Metabolic phenotypes and fatty acid profiles associated with histopathology of primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Discordance between adrenal vein sampling and imaging: the role of unilateral cortisol excess.European journal of endocrinology · 2025Article
- Unilateral Primary Aldosteronism: Long-Term Disease Recurrence After Adrenalectomy.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Adrenalectomy for primary aldosteronism and its related surgical characteristics.Frontiers in endocrinology · 2024Review
- Coexistence of Pheochromocytoma and Primary Aldosteronism due to Multiple Aldosterone-producing Micronodules in the Ipsilateral Adrenal Gland.Internal medicine (Tokyo, Japan) · 2023Article
- Diagnostic accuracy of using multiple cytokines to predict aldosterone-producing adenoma.Scientific reports · 2023Article
- In Situ Metabolomics of Cortisol-Producing Adenomas.Clinical chemistry · 2023Article
- Primary Aldosteronism: State-of-the-Art Review.American journal of hypertension · 2022Article
- The Entity of Connshing Syndrome: Primary Aldosteronism with Autonomous Cortisol Secretion.Diagnostics (Basel, Switzerland) · 2022Review
- Lateralization inEndocrinology, diabetes & metabolism · 2022Article
- [Conn's syndrome-Frequent and still too rarely diagnosed to underdiagnosed].Der Internist · 2022Review
- Characteristics of aldosterone-producing adenomas in patients without plasma renin activity suppression.PloS one · 2022Article
- Characteristics of preoperative steroid profiles and glucose metabolism in patients with primary aldosteronism developing adrenal insufficiency after adrenalectomy.Scientific reports · 2021Article
- Urine steroid profile as a new promising tool for the evaluation of adrenal tumors. Literature review.Endocrine · 2021Review
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Authors and funding
22 authors at 15 institutions in 9 countries.
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Abstract
Unilateral primary aldosteronism (PA) is the most common surgically curable form of hypertension that must be accurately differentiated from bilateral PA for therapeutic management (surgical versus medical). Adrenalectomy results in biochemical cure (complete biochemical success) in almost all patients diagnosed with unilateral PA; the remaining patients with partial or absent biochemical success comprise those with persisting aldosteronism who were misdiagnosed as unilateral PA preoperatively. To identify determinants of postsurgical biochemical outcomes, we compared the adrenal histopathology and the peripheral venous steroid profiles of patients with partial and absent or complete biochemical success after adrenalectomy for unilateral PA. A large multicenter cohort of adrenals from patients with absent and partial biochemical success (n=43) displayed a higher prevalence of hyperplasia (49% versus 21%; P=0.004) and a lower prevalence of solitary functional adenoma (44% versus 79%; P<0.001) compared with adrenals from age- and sex-matched patients with PA with complete biochemical success (n=52). We measured the peripheral plasma steroid concentrations in a subgroup of these patients (n=43) and in a group of patients with bilateral PA (n=27). Steroid profiling was associated with histopathologic phenotypes (solitary functional adenoma, hyperplasia, and aldosterone-producing cell clusters) and classified patients according to biochemical outcome or diagnosis of bilateral PA. If validated, peripheral venous steroid profiling may be a useful tool to guide the decision to perform surgery based on expectations of biochemical outcome after the procedure.
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