Evidence map›Paper›PMID 30012867›Full record

ArticleHypertension (Dallas, Tex. : 1979)2018

Impaired Trafficking of β1 Subunits Inhibits BK Channels in Cerebral Arteries of Hypertensive Rats.

M Dennis Leo, Xue Zhai, Wen Yin, Jonathan H Jaggar

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Current updates on latest basic research of scientific relevance in hypertensive dementia.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  3. CaInflammation and regeneration · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Vasodilators mobilize SK3 channels in endothelial cells to produce arterial relaxation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Loss of IP3R-BKInternational journal of molecular sciences · 2023
    Article
  10. Review
  11. Article
  12. KInternational journal of molecular sciences · 2021
    Article
  13. Review
  14. Targeting BKCNS drugs · 2020
    Review
  15. Slow Traffic Makes for Bad Circulation.Hypertension (Dallas, Tex. : 1979) · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

M Dennis LeoFrom the Department of Physiology, University of Tennessee Health Science Center, Memphis.
Xue ZhaiFrom the Department of Physiology, University of Tennessee Health Science Center, Memphis.
Wen YinFrom the Department of Physiology, University of Tennessee Health Science Center, Memphis.
Jonathan H JaggarFrom the Department of Physiology, University of Tennessee Health Science Center, Memphis.
University of Tennessee Health Science Center · US

Funding

Vascular control by K+ channel traffickingR01HL067061 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2002 to 2016
$4.8M
Endothelial cell potassium channelsR01HL137745 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2017 to 2020
$2.0M
Blood pressure regulation by smooth muscle cell ion channelsR01HL133256 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL067061NHLBI NIH HHS R01 HL133256NHLBI NIH HHS R01 HL137745
6 · The paper itself

Abstract

Hypertension is a risk factor for cerebrovascular diseases, including stroke and dementia. During hypertension, arteries become constricted and are less responsive to vasodilators, including nitric oxide (NO). The regulation of arterial contractility by smooth muscle cell (myocyte) large-conductance calcium (Ca

Indexed as

AnimalsCerebral ArteriesHypertensionIndolesLarge-Conductance Calcium-Activated Potassium ChannelsMaleMaleimidesMuscle, Smooth, VascularMyocytes, Smooth MuscleNitric Oxide DonorsNitroprussideProtein Kinase CProtein SubunitsProtein TransportRats, Inbred SHRRats, Inbred WKYbisindolylmaleimideIndolesLarge-Conductance Calcium-Activated Potassium ChannelsMaleimidesNitric Oxide DonorsNitroprussideProtein Kinase CProtein SubunitsBK channelscerebral arterieshypertensionprotein kinase Cvasodilation

Identifiers

PMID30012867
PMCPMC6202242
OpenAlexW2883308220

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.