Evidence map›Paper›PMID 30012855›Full record

ArticleDisease models & mechanisms2018

A Langendorff-like system to quantify cardiac pump function in adult zebrafish.

Hong Zhang, Alexey V Dvornikov, Inken G Huttner, Xiao Ma, Celine F Santiago, Diane Fatkin, Xiaolei Xu

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

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  8. Mechanisms ofJournal of cardiovascular development and disease · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Hong ZhangDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55902, USA.
Alexey V DvornikovDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55902, USA dvornikov.alexey@mayo.edu xu.xiaolei@mayo.edu.ORCID 0000-0003-1514-4747
Inken G HuttnerMolecular Cardiology Division, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.
Xiao MaDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55902, USA.
Celine F SantiagoMolecular Cardiology Division, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.
Diane FatkinMolecular Cardiology Division, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.
Xiaolei XuDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55902, USA dvornikov.alexey@mayo.edu xu.xiaolei@mayo.edu.ORCID 0000-0002-4928-3422
Victor Chang Cardiac Research Institute · AUMayo Clinic in Arizona · USCentral South University · CNMayo Clinic · US

Funding

Systematic Vertebrate Functional GenomicsR01GM063904 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI EKKER, STEPHEN CARL · 2001 to 2025
$10.7M
Genetic Studies of Sarcomere-based Cardiac Diseases (Diversity Supplement)R01HL081753 · NHLBI · MAYO CLINIC ROCHESTER · PI XU, XIAOLEI · 2005 to 2025
$7.8M
Epicardial remodeling in cardiomyopathy and cardiac agingR01HL107304 · NHLBI · MAYO CLINIC ROCHESTER · PI Xiaolei Xu · 2011 to 2026
$6.6M
Micro-Sensors to Study Electrical and Mechanical Coupling of Injured MyocardiumR01HL111437 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K, XU, XIAOLEI · 2012 to 2020
$3.1M
NHLBI NIH HHS R01 HL081753NHLBI NIH HHS R01 HL107304NHLBI NIH HHS R01 HL111437NIGMS NIH HHS R01 GM063904
6 · The paper itself

Abstract

Zebrafish are increasingly used as a vertebrate model to study human cardiovascular disorders. Although heart structure and function are readily visualized in zebrafish embryos because of their optical transparency, the lack of effective tools for evaluating the hearts of older, nontransparent fish has been a major limiting factor. The recent development of high-frequency echocardiography has been an important advance for

Indexed as

AgingAnimalsCardiomyopathiesDoxorubicinElectrocardiographyFemaleHeartHeart VentriclesMaleMyocardial ContractionOrgan SizePerfusionZebrafishDoxorubicinCardiac contractilityCardiac pump functionLangendorffZebrafish

Identifiers

PMID30012855
PMCPMC6177000
OpenAlexW2883195800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.