Evidence map›Paper›PMID 30012849›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

2B4 Mediates Inhibition of CD8

Sonia J Laurie, Danya Liu, Maylene E Wagener, Phoebe C Stark, Cox Terhorst, Mandy L Ford

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Immunometabolism of CD8Trends in cancer · 2024
    Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sonia J LaurieEmory Transplant Center, Atlanta, GA 30322; and.
Danya LiuEmory Transplant Center, Atlanta, GA 30322; and.ORCID 0000-0001-6103-6486
Maylene E WagenerEmory Transplant Center, Atlanta, GA 30322; and.
Phoebe C StarkEmory Transplant Center, Atlanta, GA 30322; and.ORCID 0000-0002-3228-1666
Cox TerhorstBeth Israel Deaconess Medical Center, Boston, MA 02215.ORCID 0000-0001-6233-7029
Mandy L FordEmory Transplant Center, Atlanta, GA 30322; and mandy.ford@emory.edu.ORCID 0000-0001-6736-4421
Emory Healthcare · USBeth Israel Deaconess Medical Center · US

Funding

Enhancing immune regulation in gene therapy for hemophiliaR01HL131093 · NHLBI · UNIVERSITY OF FLORIDA · PI Ype Peter De Jong, Roland W. Herzog · 2016 to 2026
$7.2M
TRAINING IN IMMUNOLOGY AND MOLECULAR PATHOGENESIST32AI007610 · NIAID · EMORY UNIVERSITY · PI EVAVOLD, BRIAN D · 2000 to 2014
$4.4M
Determinants of T Cell Fate in Transplantation ToleranceR01AI073707 · NIAID · EMORY UNIVERSITY · PI FORD, MANDY L · 2008 to 2021
$4.0M
Costimulatory and Coinhibitory Receptor Control of Alloreactive T Cell ResponsesR01AI104699 · NIAID · EMORY UNIVERSITY · PI FORD, MANDY L · 2013 to 2017
$2.1M
Targeting 2B4 Coinhibitory Signals During Sepsis-Induced Immune DysregulationR01GM113228 · NIGMS · EMORY UNIVERSITY · PI COOPERSMITH, CRAIG M, FORD, MANDY L · 2015 to 2018
$1.2M
The Role of 2B4 Coinhibition in Transplantation and ImmunityF31AI114250 · NIAID · EMORY UNIVERSITY · PI LAURIE, SONIA JESSICA · 2014 to 2017
$173k
NIAID NIH HHS F31 AI114250NIAID NIH HHS R01 AI073707NIAID NIH HHS R01 AI104699NIAID NIH HHS T32 AI007610NIGMS NIH HHS R01 GM113228
6 · The paper itself

Abstract

We recently showed that 2B4 expression on memory T cells in human renal transplant recipients was associated with reduced rates of rejection. To investigate whether 2B4 functionally underlies graft acceptance during transplantation, we established an experimental model in which 2B4 was retrogenically expressed on donor-reactive murine CD8

Indexed as

Lymphocyte ActivationSkin TransplantationAnimalsCD8-Positive T-LymphocytesCell DivisionGlycolysisGraft SurvivalMiceMice, KnockoutSignaling Lymphocytic Activation Molecule FamilySignal TransductionCd244a protein, mouseSignaling Lymphocytic Activation Molecule Family

Identifiers

PMID30012849
PMCPMC6103805
OpenAlexW2884987252

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.