Evidence map›Paper›PMID 30012848›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

B Cell Defects Observed in

Serre-Yu Wong, Maryaline Coffre, Deepshika Ramanan, Marcus J Hines, Luis E Gomez, Lauren A Peters, Eric E Schadt, Sergei B Koralov, Ken Cadwell

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Mice Dually Disrupted forFrontiers in immunology · 2022
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Spontaneous Loss-of-FunctionCrohn's & colitis 360 · 2019
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Serre-Yu WongKimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016.ORCID 0000-0002-2070-4123
Maryaline CoffreDepartment of Pathology, New York University School of Medicine, New York, NY 10016.
Deepshika RamananKimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016.
Marcus J HinesDepartment of Pathology, New York University School of Medicine, New York, NY 10016.
Luis E GomezKimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016.
Lauren A PetersDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0002-3747-0474
Eric E SchadtDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Sergei B KoralovDepartment of Pathology, New York University School of Medicine, New York, NY 10016.
Ken CadwellKimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016; Ken.Cadwell@med.nyu.edu Sergei.Koralov@nyumc.org.ORCID 0000-0002-5860-0661
New York University · USSema4 (United States) · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
MEDICAL SCIENTIST TRAININGT32GM007308 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PHILIPS, MARK REID · 1985 to 2019
$23.2M
Diabetes, Digestive, and Kidney Diseases Extramural ResearchR01DK093668 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2011 to 2026
$7.3M
Redefining the role of autophagy in bacterial diseaseR01AI121244 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2017 to 2026
$5.6M
The role of autophagy gene Atg16L1 in allogeneic hematopoietic stem cell transplantation - Resubmission - 1R01HL123340 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA, VAN DEN BRINK, MARCEL R M · 2015 to 2022
$5.2M
Interactions between helminth colonization and the gut microbiotaR01AI130945 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA · 2018 to 2022
$3.3M
Microbial triggers and molecular mechanisms of Th17 mediated airway inflammation-Resubmission-1R01HL125816 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KORALOV, SERGEI BORISOVICH · 2015 to 2019
$3.3M
Role of Nod2 in preventing intestinal disease downstream of microbial imbalancesR01DK103788 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA, LOKE, PNG · 2015 to 2017
$1.3M
Generation of a mouse expressing a photoactivatable Cre recombinaseR21AI124129 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KORALOV, SERGEI BORISOVICH, SCHWAB, SUSAN RUTH · 2016 to 2017
$466k
Non-coding RNAs in B lymphocyte development and functionR21AI110830 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KORALOV, SERGEI BORISOVICH · 2014 to 2014
$170k
Howard Hughes Medical InstituteNCI NIH HHS P30 CA016087NHLBI NIH HHS R01 HL123340NHLBI NIH HHS R01 HL125816NIAID NIH HHS R01 AI121244NIAID NIH HHS R01 AI130945NIAID NIH HHS R21 AI110830NIAID NIH HHS R21 AI124129NIDDK NIH HHS R01 DK093668NIDDK NIH HHS R01 DK103788NIGMS NIH HHS T32 GM007308
6 · The paper itself

Abstract

Phenotypic differences among substrains of laboratory mice due to spontaneous mutations or pre-existing genetic variation confound the interpretation of targeted mutagenesis experiments and contribute to challenges with reproducibility across institutions. Notably, C57BL/6 Hsd mice and gene-targeted mice that have been backcrossed to this substrain have been reported to harbor a duplication in exons 28 and 29 of

Indexed as

GTPase-Activating ProteinsImmune System DiseasesMutationAnimalsB-LymphocytesGuanine Nucleotide Exchange FactorsMiceMice, KnockoutNod2 Signaling Adaptor ProteinDOCK2 protein, mouseGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsNod2 protein, mouseNod2 Signaling Adaptor Protein

Identifiers

PMID30012848
PMCPMC6103850
OpenAlexW2952197184

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.