Evidence map›Paper›PMID 30012842›Full record

ArticleThe Journal of general physiology2018

The TMEM16A channel mediates the fast polyspermy block in

Katherine L Wozniak, Wesley A Phelps, Maiwase Tembo, Miler T Lee, Anne E Carlson

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of general physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Interplay of CaThe Journal of physiology · 2026
    Article
  5. Article
  6. Fertilization in the African clawed frogmicroPublication biology · 2025
    Article
  7. Article
  8. Article
  9. Effect of Synthetic Vitreous Fiber Exposure on TMEM16A Channels in aInternational journal of molecular sciences · 2024
    Article
  10. Article
  11. Article
  12. bioRxiv : the preprint server for biology · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. The CaActa pharmaceutica Sinica. B · 2021
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Katherine L WozniakDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA.
Wesley A PhelpsDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA.ORCID 0000-0002-4056-2345
Maiwase TemboDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA.ORCID 0000-0001-7562-3606
Miler T LeeDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA.ORCID 0000-0003-0933-0551
Anne E CarlsonDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA acarlson@pitt.edu.ORCID 0000-0003-2724-1325
University of Pittsburgh · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Signaling Mechanisms of Polyspermy BlockR00HD069410 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARLSON, ANNE E · 2014 to 2016
$730k
NICHD NIH HHS R00 HD069410NIDDK NIH HHS P30 DK079307
6 · The paper itself

Abstract

In externally fertilizing animals, such as sea urchins and frogs, prolonged depolarization of the egg immediately after fertilization inhibits the entry of additional sperm-a phenomenon known as the fast block to polyspermy. In the African clawed frog

Indexed as

FertilizationAcetamidesAmbystoma mexicanumAnimalsAnoctamin-1BestrophinsChloride ChannelsFemaleHydrazonesortho-AminobenzoatesOvumPatch-Clamp TechniquesXenopus laevisAcetamidesAni9 compoundAnoctamin-1BestrophinsChloride ChannelsHydrazonesN-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acidortho-Aminobenzoates

Identifiers

PMID30012842
PMCPMC6122928
OpenAlexW2950149299

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.