Evidence map›Paper›PMID 30012774›Full record

ArticleAntimicrobial agents and chemotherapy2018

Robert A Smith, Vincent H Wu, Christopher G Zavala, Dana N Raugi, Selly Ba, Moussa Seydi, Geoffrey S Gottlieb, University of Washington-Dakar HIV-2 Study Group

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Robert A SmithCenter for Emerging and Reemerging Infectious Diseases and Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA smithra@u.washington.edu.
Vincent H WuCenter for Emerging and Reemerging Infectious Diseases and Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
Christopher G ZavalaCenter for Emerging and Reemerging Infectious Diseases and Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
Dana N RaugiCenter for Emerging and Reemerging Infectious Diseases and Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
Selly BaService des Maladies Infectieuses et Tropicales, CHNU de Fann, Dakar, Senegal.
Moussa SeydiService des Maladies Infectieuses et Tropicales, CHNU de Fann, Dakar, Senegal.
Geoffrey S GottliebCenter for Emerging and Reemerging Infectious Diseases and Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
University of Washington-Dakar HIV-2 Study Group

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Kenneth Sherr · 1988 to 2026
$104.9M
Improving Diagnosis, Treatment & Detection of Drug Resistance in HIV-2 InfectionR01AI120765 · NIAID · UNIVERSITY OF WASHINGTON · PI Geoffrey Scott Gottlieb · 2015 to 2026
$8.9M
Antiretroviral Therapy for HIV-2 Infection in SenegalR01AI060466 · NIAID · UNIVERSITY OF WASHINGTON · PI GOTTLIEB, GEOFFREY SCOTT · 2005 to 2014
$6.5M
NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI060466NIAID NIH HHS R01 AI120765
6 · The paper itself

Abstract

We examined the antiviral activity of the integrase inhibitor (INI) cabotegravir against HIV-2 isolates from INI-naive individuals. HIV-2 was sensitive to cabotegravir in single-cycle and spreading-infection assays, with 50% effective concentrations (EC

Indexed as

Anti-HIV AgentsDiketopiperazinesHIV-1HIV-2PyridonesAnti-HIV AgentscabotegravirDiketopiperazinesPyridonesantiretroviral therapycabotegravirHIV-2human immunodeficiency virusPrEPtreatmentWest Africa

Identifiers

PMID30012774
PMCPMC6153831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.