Evidence map›Paper›PMID 30012773›Full record

ArticleAntimicrobial agents and chemotherapy2018

Effective Treatment of Mycobacterium avium subsp. hominissuis and Mycobacterium abscessus Species Infections in Macrophages, Biofilm, and Mice by Using Liposomal Ciprofloxacin.

James D Blanchard, Valerie Elias, David Cipolla, Igor Gonda, Luiz E Bermudez

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Sequence of Antibiotic Administration for the Treatment ofAntibiotics (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
  5. Microorganisms · 2025
    Review
  6. Article
  7. Nitric oxide-releasing prodrug for the treatment of complexAntimicrobial agents and chemotherapy · 2024
    Article
  8. A laboratory perspective onFrontiers in microbiology · 2024
    Review
  9. Review
  10. Article
  11. Metabolic pathways that permitFrontiers in cellular and infection microbiology · 2023
    Article
  12. Liposomal drug delivery to manage nontuberculous mycobacterial pulmonary disease and other chronic lung infections.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  13. Review
  14. Nanobiosystems for Antimicrobial Drug-Resistant Infections.Nanomaterials (Basel, Switzerland) · 2021
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Frontiers in microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

James D BlanchardAradigm Corporation, Hayward, California, USA.
Valerie EliasDepartment of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA.
David CipollaAradigm Corporation, Hayward, California, USA.
Igor GondaAradigm Corporation, Hayward, California, USA.
Luiz E BermudezDepartment of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA luiz.bermudez@oregonstate.edu.
Aradigm (United States) · USOregon State University · US

Funding

In vitro and in vivo efficacy of liposomal ciprofloxacin formulations against MycR43AI106188 · NIAID · ARADIGM CORPORATION · PI BERMUDEZ, LUIZ EDUARDO, BLANCHARD, JAMES D · 2013 to 2013
$278k
NIAID NIH HHS R43 AI106188
6 · The paper itself

Abstract

Nontuberculous mycobacteria (NTM) affect an increasing number of individuals worldwide. Infection with these organisms is more common in patients with chronic lung conditions, and treatment is challenging. Quinolones, such as ciprofloxacin, have been used to treat patients, but the results have not been encouraging. In this report, we evaluate novel formulations of liposome-encapsulated ciprofloxacin (liposomal ciprofloxacin)

Indexed as

AnimalsBiofilmsFemaleHumansLiposomesMacrophagesMiceMice, Inbred C57BLMicrobial Sensitivity TestsMycobacterium abscessusMycobacterium aviumPolyethylene GlycolsLiposomesPolyethylene Glycolsbiofilmciprofloxacininfectionliposomelung diseasemouse modelMycobacterium abscessusMycobacterium aviumMycobacterium avium subsp. hominissuistreatment

Identifiers

PMID30012773
PMCPMC6153787
OpenAlexW2884573239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.