Evidence map›Paper›PMID 30012752›Full record

ArticleAntimicrobial agents and chemotherapy2018

Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity.

Seong Won Choi, Yuexi Gu, Ryan Scott Peters, Padmini Salgame, Jerrold J Ellner, Graham S Timmins, Vojo Deretic

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 46 citations in OpenAlex.

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  7. Host-directed therapy for tuberculosis.European journal of medical research · 2025
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  14. Fountain of youth-Targeting autophagy in aging.Frontiers in aging neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Seong Won Choi *Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Yuexi Gu *Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Ryan Scott Peters *Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Padmini SalgameDivision of Infectious Disease, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Jerrold J EllnerDivision of Infectious Disease, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Graham S TimminsDepartment of Pharmaceutical Sciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA gtimmins@salud.unm.edu vderetic@salud.unm.edu.
Vojo DereticDepartment of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA gtimmins@salud.unm.edu vderetic@salud.unm.edu.
University of New Mexico · USBoston University · USRutgers, The State University of New Jersey · US

Funding

Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI VOJO P DERETIC · 2017 to 2026
$24.9M
Autophagy Against Tuberculosis and HIVR01AI111935 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI DERETIC, VOJO P · 2014 to 2023
$7.0M
Pattern Recognition Receptors and Autophagy in Mtb Control in AIDSR37AI042999 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI VOJO P DERETIC · 2018 to 2026
$4.7M
Autophagy-based HDT for tuberculosisUH2AI122313 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI DERETIC, VOJO P, ELLNER, JERROLD J. · 2015 to 2016
$1.1M
NIAID NIH HHS R01 AI111935NIAID NIH HHS R37 AI042999NIAID NIH HHS UH2 AI122313NIGMS NIH HHS P20 GM121176
6 · The paper itself

Abstract

Host-directed therapy in tuberculosis is a potential adjunct to antibiotic chemotherapy directed at

Indexed as

AmbroxolAnimalsAntitubercular AgentsAutophagyMacrophagesMiceMice, Inbred C57BLMycobacterium tuberculosisRifampinTuberculosisAmbroxolAntitubercular AgentsRifampinautophagyMycobacterium tuberculosis

Identifiers

PMID30012752
PMCPMC6125555
OpenAlexW2880443987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.