ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Differentiation of Human Medial Prefrontal Cortex Activity Underlies Long-Term Resistance to Forgetting in Memory.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The human hippocampus can pattern separate memories by meaning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Role of Rapid Eye Movement Sleep in Neural Differentiation of Memories in the Hippocampus.Journal of cognitive neuroscience · 2026Article
- Salient Memory: Effects of Distributed Learning on Cortical Regions During Memory Retrieval.Human brain mapping · 2025Article
- Time-dependent consolidation mechanisms of durable memory in spaced learning.Communications biology · 2025Article
- Benefits of spaced learning are predicted by the re-encoding of past experience in ventromedial prefrontal cortex.Cell reports · 2025Article
- Pattern integration and differentiation: Dual process model of episodic memory.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Benefits of spaced learning are predicted by re-encoding of past experience in ventromedial prefrontal cortex.bioRxiv : the preprint server for biology · 2024Article
- Cognition-Emotion Interaction during L2 Sentence Comprehension: The Correlation of ERP and GSR Responses to Sense Combinations.Journal of psycholinguistic research · 2024Article
- Neural similarity between overlapping events at learning differentially affects reinstatement across the cortex.NeuroImage · 2023Article
- Structured memory representations develop at multiple time scales in hippocampal-cortical networks.bioRxiv : the preprint server for biology · 2023Article
- A smartphone intervention that enhances real-world memory and promotes differentiation of hippocampal activity in older adults.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Data-Driven Clustering of Functional Signals Reveals Gradients in Processing Both within the Anterior Hippocampus and across Its Long Axis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Has the concept of systems consolidation outlived its usefulness? Identification and evaluation of premises underlying systems consolidation.Faculty reviews · 2022Review
- Neural Evidence for Representational Persistence Within Events.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Time-dependent transformations of memory representations differ along the long axis of the hippocampus.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Multisensory Input Modulates P200 and L2 Sentence Comprehension: A One-Week Consolidation Phase.Frontiers in psychology · 2021Article
- Sleep Spindles Promote the Restructuring of Memory Representations in Ventromedial Prefrontal Cortex through Enhanced Hippocampal-Cortical Functional Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Oxygenation of the Prefrontal Cortex during Memory Interference.Journal of clinical medicine · 2019Article
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3 authors.
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Abstract
It is well known that distributing study events over time leads to better memory over long time scales, compared with massing study events together. One explanation for such long-term resistance to forgetting is that distributed study leads to neural differentiation in memory, which supports retrieval of past experiences by disambiguating highly similar memory representations. Neuroanatomical models of episodic memory retrieval propose that the hippocampus and medial prefrontal cortex (MPFC) work together to enable retrieval of behaviorally appropriate memories. However, it is not known how representations in these regions jointly support resistance to forgetting long after initial learning. Using fMRI, we measured differentiation in retrieved memory representations following an extended delay in male and female human participants. After 1 week, word-object associations were better remembered if studied across 2 d (overnight), allowing associations to be learned in distinct temporal contexts, compared with learning within a single day (same day). MPFC retrieval patterns showed differentiation for overnight relative to same day memories, whereas hippocampal patterns reflected associative retrieval success. Overnight memory differentiation in MPFC was higher for associative than item memories and higher than differentiation assessed over a brain-wide set of retrieval-active voxels. The memory-related difference in MPFC pattern differentiation correlated with memory success for overnight learning and with hippocampal-MPFC functional connectivity. These results show that learning information across days leads to differentiated MPFC memory representations, reducing forgetting after 1 week, and suggest this arises from persistent interactions between MPFC and hippocampus.
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