Evidence map›Paper›PMID 30012693›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Persistent Sodium Current Drives Excitability of Immature Renshaw Cells in Early Embryonic Spinal Networks.

Juliette Boeri, Hervé Le Corronc, François-Xavier Lejeune, Barbara Le Bras, Christine Mouffle, Monara Kaelle S C Angelim, Jean-Marie Mangin, Pascal Branchereau, Pascal Legendre, Antonny Czarnecki

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Juliette BoeriINSERM, UMR_S 1130, CNRS, UMR 8246, Neuroscience Paris Seine, Institute of Biology Paris Seine, 75005 Paris, France.
Hervé Le CorroncINSERM, UMR_S 1130, CNRS, UMR 8246, Neuroscience Paris Seine, Institute of Biology Paris Seine, 75005 Paris, France.
François-Xavier LejeuneINSERM, UMR_S 1130, CNRS, UMR 8246, Neuroscience Paris Seine, Institute of Biology Paris Seine, 75005 Paris, France.
Barbara Le BrasINSERM, UMR_S 1130, CNRS, UMR 8246, Neuroscience Paris Seine, Institute of Biology Paris Seine, 75005 Paris, France.
Christine MouffleINSERM, UMR_S 1130, CNRS, UMR 8246, Neuroscience Paris Seine, Institute of Biology Paris Seine, 75005 Paris, France.
Monara Kaelle S C AngelimINSERM, UMR_S 1130, CNRS, UMR 8246, Neuroscience Paris Seine, Institute of Biology Paris Seine, 75005 Paris, France.
Jean-Marie ManginINSERM, UMR_S 1130, CNRS, UMR 8246, Neuroscience Paris Seine, Institute of Biology Paris Seine, 75005 Paris, France.
Pascal BranchereauUniversity Bordeaux, INCIA, UMR 5287, F-33615 Pessac, France, and.ORCID 0000-0003-3972-8229
Pascal LegendreINSERM, UMR_S 1130, CNRS, UMR 8246, Neuroscience Paris Seine, Institute of Biology Paris Seine, 75005 Paris, France, antonny.czarnecki@sorbonne-universite.fr pascal.legendre@inserm.fr.ORCID 0000-0002-5086-4515
Antonny CzarneckiINSERM, UMR_S 1130, CNRS, UMR 8246, Neuroscience Paris Seine, Institute of Biology Paris Seine, 75005 Paris, France, antonny.czarnecki@sorbonne-universite.fr pascal.legendre@inserm.fr.ORCID 0000-0002-5104-034X
Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spontaneous network activity (SNA) emerges in the spinal cord (SC) before the formation of peripheral sensory inputs and central descending inputs. SNA is characterized by recurrent giant depolarizing potentials (GDPs). Because GDPs in motoneurons (MNs) are mainly evoked by prolonged release of GABA, they likely necessitate sustained firing of interneurons. To address this issue we analyzed, as a model, embryonic Renshaw cell (V1

Indexed as

Action PotentialsAnimalsExcitatory Amino Acid AntagonistsFemaleGABAergic NeuronsGene Knock-In TechniquesMaleMiceMice, Inbred C57BLMice, TransgenicMotor NeuronsNerve NetParacrine CommunicationPatch-Clamp TechniquesRenshaw CellsRiluzoleExcitatory Amino Acid AntagonistsRiluzoleSodiumSodium Channelsdevelopmentexcitabilitymouse embryopersistent sodium currentRenshaw cellspontaneous network activity

Identifiers

PMID30012693
PMCPMC6705967
OpenAlexW2885021547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.