ArticleProceedings of the National Academy of Sciences of the United States of America2018
Hippocampus-dependent emergence of spatial sequence coding in retrosplenial cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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66 citing papers in PubMed.
- Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation.eLife · 2026Article
- A transparent wheel-based platform for locomotion-on-demand and multi-view body and facial kinematics in head-fixed mice.Scientific reports · 2026Article
- Anterior and posterior retrosplenial cortex form distinct visuospatial circuits in the mouse.Nature communications · 2026Article
- Place field dynamics in retrosplenial cortex compared to hippocampus.Progress in neurobiology · 2026Article
- Environmental enrichment accelerates the stabilization of cortical representation duringiScience · 2026Article
- Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation.bioRxiv : the preprint server for biology · 2025Article
- Working memory expands shared task representations in cortex.bioRxiv : the preprint server for biology · 2025Article
- Environmental enrichment accelerates cortical memory consolidation.bioRxiv : the preprint server for biology · 2025Article
- Brain region-specific gain modulation of place cells by VIP neurons.Nature communications · 2025Article
- A flexible hippocampal population code for experience relative to reward.Nature neuroscience · 2025Article
- Dissection of the long-range circuit of the mouse intermediate retrosplenial cortex.Communications biology · 2025Article
- Representational similarity analysis reveals cue-independent spatial representations for landmarks and self-motion cues in human retrosplenial cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Physiological characteristics of neurons in the mammillary bodies align with topographical organization of subicular inputs.Cell reports · 2024Article
- Learning to use landmarks for navigation amplifies their representation in retrosplenial cortex.bioRxiv : the preprint server for biology · 2024Article
- Hierarchical Gradients of Encoded Spatial and Sensory Information in the Neocortex Are Attenuated by Dorsal Hippocampal Lesions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Differentiated somatic gene expression is triggered in the dorsal hippocampus and the anterior retrosplenial cortex by hippocampal synaptic plasticity prompted by spatial content learning.Brain structure & function · 2024Article
- Time Cells in the Retrosplenial Cortex.bioRxiv : the preprint server for biology · 2024Article
- Hippocampal sequences span experience relative to rewards.bioRxiv : the preprint server for biology · 2024Article
- Coordinated Interactions between the Hippocampus and Retrosplenial Cortex in Spatial Memory.Research (Washington, D.C.) · 2024Article
- Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue.Nature communications · 2023Article
6 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
Retrosplenial cortex (RSC) is involved in visuospatial integration and spatial learning, and RSC neurons exhibit discrete, place cell-like sequential activity that resembles the population code of space in hippocampus. To investigate the origins and population dynamics of this activity, we combined longitudinal cellular calcium imaging of dysgranular RSC neurons in mice with excitotoxic hippocampal lesions. We tracked the emergence and stability of RSC spatial activity over consecutive imaging sessions. Overall, spatial activity in RSC was experience-dependent, emerging gradually over time, but, as seen in the hippocampus, the spatial code changed dynamically across days. Bilateral but not unilateral hippocampal lesions impeded the development of spatial activity in RSC. Thus, the emergence of spatial activity in RSC, a major recipient of hippocampal information, depends critically on an intact hippocampus; the indirect connections between the dysgranular RSC and the hippocampus further indicate that hippocampus may exert such influences polysynaptically within neocortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.