ArticleProceedings of the National Academy of Sciences of the United States of America2018
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
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113citing papers in PubMed
8.4field-weighted citation impact, top 1% of its field
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Who cites it
113 citing papers in PubMed, 175 citations in OpenAlex.
- Trial
- The protease code of the bacterial gut microbiota: ecological regulation, barrier disruption, and rewiring host defense and signaling.Gut microbes · 2026Review
- Dual-Targeted Inhibition of PARNanomaterials (Basel, Switzerland) · 2026Article
- Oncogenic Gα signaling requires AP-3-dependent recruitment to the endolysosomal compartment.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Monoclonal antibody inhibition of PAR2 reduces phenotype severity and pain in murine inflammatory bowel disease.Pain reports · 2026Article
- Article
- MMP1 and PRSS23 induce PARCommunications biology · 2026Article
- Protease-Activated Receptor-2 Promotes Metastasis: An Emerging Therapeutic Target.Molecular cancer research : MCR · 2026Review
- The Mast Cell-PAR2-TRP Axis: A Convergent Mechanism for Visceral Hypersensitivity Independent of Divergent Motility in IBS.Biomolecules · 2026Review
- Identifying microbial protease allergens through protein language model-guided homology.Cell systems · 2026Article
- Mas-Related G-Protein-Coupled Receptors: Emerging Roles in Neuropathic Pain.Biomolecules · 2026Review
- Electrophysiological and Proteomic Evidence of Protease-Mediated Pro-nociceptive Signaling in Inflammatory Bowel Disease Patients.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Proteases and Abdominal Pain-Old Dog, New (Microbial) Tricks.Cellular and molecular gastroenterology and hepatology · 2026Review
- Endosomal MrGPRX1 signaling sensitizes TRPV1 to enhance itch.Frontiers in molecular neuroscience · 2026Article
- Endosomal MrGPRX1 signaling sensitizes TRPV1 to enhance itch.bioRxiv : the preprint server for biology · 2025Article
- Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Bacteroides fragilis protease activates host PARCell host & microbe · 2025Article
- Emerging therapeutic approaches for treating abdominal pain.Journal of the Canadian Association of Gastroenterology · 2025Review
- Receptor activity-modifying protein 3 enhances GLP-1-mediated insulin secretion.The Journal of biological chemistry · 2025Article
- Plasma membrane rather than endosomal Gq signaling drives transcriptional activity by the viral chemokine receptor US28 in glioblastoma.bioRxiv : the preprint server for biology · 2025Article
53 more citing papers are in PubMed but not listed here.
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Authors and funding
27 authors at 6 institutions in 3 countries.
Nestor N Jimenez-VargasGastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON K7L 2V7, Canada.
Luke A PattisonMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
Peishen ZhaoMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
TinaMarie LieuMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
Rocco LatorreDepartment of Surgery, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Dane D JensenDepartment of Surgery, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Joel CastroVisceral Pain Research Group, Human Physiology, Centre for Neuroscience, Flinders University, Adelaide, SA 5000, Australia.
Luigi AurelioMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
Giang T LeMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
Bernard FlynnMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
Carmen Klein HerenbrinkMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
Holly R YeatmanMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
Laura Edgington-MitchellMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
Christopher J H PorterMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.ORCID 0000-0003-3474-7551
Michelle L HallsMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
Meritxell CanalsMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
Nicholas A VeldhuisMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
Daniel P PooleMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
Peter McLeanGastrointestinal Drug Discovery Unit, Takeda Pharmaceuticals, Inc., Cambridge, MA 02139.
Gareth A HicksGastrointestinal Drug Discovery Unit, Takeda Pharmaceuticals, Inc., Cambridge, MA 02139.
Nicole ScheffBluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Elyssa ChenBluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Aditi BhattacharyaBluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Brian L SchmidtBluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Stuart M BrierleyVisceral Pain Research Group, Human Physiology, Centre for Neuroscience, Flinders University, Adelaide, SA 5000, Australia.
Stephen J VannerGastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON K7L 2V7, Canada.
Nigel W BunnettMonash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia; nb2733@cumc.columbia.edu.
Australian Research Council · AUCenter for Clinical Research (United States) · USColumbia University · USFlinders University · AUQueen's University · CATakeda (United States) · US
Funding
Protease/PAR2/TRPV4 Axis and Oral Cancer PainR01DE026806 · NIDCR · NEW YORK UNIVERSITY · PI BUNNETT, NIGEL W, SCHMIDT, BRIAN L · 2018 to 2022
$3.9MEndosomal Platforms for Signaling PainR01NS102722 · NINDS · NEW YORK UNIVERSITY · PI NIGEL W BUNNETT, Brian L Schmidt · 2017 to 2026
$3.4MTrafficking-Dependent Signaling of Pain by Protease-Activated ReceptorsR01DK118971 · NIDDK · NEW YORK UNIVERSITY · PI BUNNETT, NIGEL W, SCHMIDT, BRIAN L · 2018 to 2021
$3.2MNon-viral gene therapy for cancer painR01DE025393 · NIDCR · NEW YORK UNIVERSITY · PI SCHMIDT, BRIAN L, YAMANO, SEIICHI · 2016 to 2018
$1.3MNon-viral gene therapy for cancer pain.R56DE025393 · NIDCR · NEW YORK UNIVERSITY · PI SCHMIDT, BRIAN L, YAMANO, SEIICHI · 2015 to 2015
$396kNIDCR NIH HHS R01 DE025393NIDCR NIH HHS R01 DE026806NIDCR NIH HHS R56 DE025393NINDS NIH HHS R01 NS102722
Abstract
Once activated at the surface of cells, G protein-coupled receptors (GPCRs) redistribute to endosomes, where they can continue to signal. Whether GPCRs in endosomes generate signals that contribute to human disease is unknown. We evaluated endosomal signaling of protease-activated receptor-2 (PAR
Indexed as
AnimalsChronic PainEndocytosisEndosomesExtracellular Signal-Regulated MAP KinasesHumansIrritable Bowel SyndromeNociceptionNociceptorsReceptor, PAR-2Signal TransductionTrypsinExtracellular Signal-Regulated MAP KinasesReceptor, PAR-2Trypsinendosomespainproteasesreceptors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.