Evidence map›Paper›PMID 30012568›Full record

ArticleRNA (New York, N.Y.)2018

Increasing the length of poly-pyrimidine bulges broadens RNA conformational ensembles with minimal impact on stacking energetics.

Dawn K Merriman, Jiayi Yuan, Honglue Shi, Ananya Majumdar, Daniel Herschlag, Hashim M Al-Hashimi

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Probing RNA Structures and Interactions Using Fluorescence Lifetime Analyses.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  6. Article
  7. Article
  8. Exposing Hidden High-Affinity RNA Conformational States.Journal of the American Chemical Society · 2020
    Article
  9. The roles of structural dynamics in the cellular functions of RNAs.Nature reviews. Molecular cell biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Dawn K MerrimanDepartment of Chemistry, Duke University, Durham, North Carolina 27708, USA.ORCID 0000-0002-0333-5485
Jiayi YuanDepartment of Chemistry, Duke University, Durham, North Carolina 27708, USA.
Honglue ShiDepartment of Chemistry, Duke University, Durham, North Carolina 27708, USA.ORCID 0000-0003-3847-1652
Ananya MajumdarBiomolecular NMR Facility, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Daniel HerschlagDepartment of Biochemistry, Stanford University, Stanford, California 94305, USA.ORCID 0000-0002-4685-1973
Hashim M Al-HashimiDepartment of Chemistry, Duke University, Durham, North Carolina 27708, USA.
Duke University · USJohns Hopkins University · USStanford University · US

Funding

Time-resolved small angle X-ray scatteringP01GM066275 · NIGMS · STANFORD UNIVERSITY · PI HERSCHLAG, DANIEL · 2003 to 2017
$17.8M
NIGMS NIH HHS P01 GM066275
6 · The paper itself

Abstract

Helical elements separated by bulges frequently undergo transitions between unstacked and coaxially stacked conformations during the folding and function of noncoding RNAs. Here, we examine the dynamic properties of poly-pyrimidine bulges of varying length (

Indexed as

Nucleic Acid ConformationPyrimidinesHIV-1HumansMagnesiumMagnetic Resonance SpectroscopyPolyribonucleotidesResponse ElementsRNA, ViralStructure-Activity RelationshipMagnesiumPolyribonucleotidesPyrimidinesRNA, ViralHIVHJH motifsNMRRNA bulgesRNA dynamicsRNA folding

Identifiers

PMID30012568
PMCPMC6140463
OpenAlexW2883194399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.