ArticleInternational journal of antimicrobial agents2018
Comparative efficacy of antibiotics in treating experimental Clostridium septicum infection.
Article in International journal of antimicrobial agents, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Pediatric Clostridium septicum infections: a systematic review and case-based perspective.BMC pediatrics · 2026Pooled it
- Case Report: A case of severe infection caused byFrontiers in medicine · 2026Article
- Clostridium septicum causing aortic aneurysm, spondylodiscitis, and epidural abscess in an immunocompetent man.BMC infectious diseases · 2025Article
- Gas gangrene with Clostridium septicum in a neutropenic patient.Infection · 2025Article
- Clostridial Myonecrosis: A Comprehensive Review of Toxin Pathophysiology and Management Strategies.Microorganisms · 2024Review
- Anti-tumor Effects of Recombinant Clostridium α-Toxin on Breast Cancer: AnInternational journal of molecular and cellular medicine · 2024Article
- Clostridial Catastrophe in Orthopedics - A Case Report.Journal of orthopaedic case reports · 2024Article
- Fatal Clostridium septicum gas gangrene complicating ECMO: case report and review of literature.Access microbiology · 2024Article
- Article
- Clostridium myonecrosis - a rare and underdiagnosed condition in the elderly: a case with severe skipping lesions and an overview of treatment guidelines.International journal of emergency medicine · 2022Article
- Vertebral augmentation-relatedRadiology case reports · 2022Article
- Regional pattern and signatures of gut microbiota in rural residents with coronary heart disease: A metagenomic analysis.Frontiers in cellular and infection microbiology · 2022Article
- Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2021Article
- First Comparative Analysis ofFrontiers in microbiology · 2021Article
- Article
- Clostridial Gas Gangrene - A Rare but Deadly Infection: Case series and Comparison to Other Necrotizing Soft Tissue Infections.Orthopaedic surgery · 2020Article
- Distant myonecrosis by atraumaticIDCases · 2020Article
- Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Clostridium septicum is a highly pathogenic microbe that causes gas gangrene in humans, and is the principal cause of spontaneous gas gangrene in patients with gastrointestinal maladies, including adenocarcinoma of the colon. Despite modern approaches to manage C. septicum infection, morbidity and mortality remain high (>60%). At present, no objective in-vivo data exist supporting the current antibiotic treatment recommendations for C. septicum infection. Utilizing an established murine model of clostridial myonecrosis, this study investigated the efficacy of standard antibiotics for anaerobic Gram-positive soft tissue infections (penicillin, clindamycin, tetracycline and vancomycin) in treating C. septicum gas gangrene. Following intramuscular challenge with 1 × 10
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Registered trials
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