Trial reportThe Lancet. Global health2018
Exposure to improved nutrition from conception to age 2 years and adult cardiometabolic disease risk: a modelling study.
Trial report in The Lancet. Global health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Infant fat mass and later child and adolescent health outcomes: a systematic review.Archives of disease in childhood · 2024Pooled it
- Early-Life Nutrition Interventions and Associated Long-Term Cardiometabolic Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Findings from the Tushirikiane mobile health (mHealth) HIV self-testing pragmatic trial with refugee adolescents and youth living in informal settlements in Kampala, Uganda.Journal of the International AIDS Society · 2023Trial
- Postprandial glycemic response differed by early life nutritional exposure in a longitudinal cohort: a single- and multi-biomarker approach.European journal of nutrition · 2021Trial
- Macronutrient, Energy, and Bile Acid Metabolism Pathways Altered Following a Physiological Meal Challenge, Relative to Fasting, among Guatemalan Adults.The Journal of nutrition · 2020Trial
- Overweight and Obesity, Cardiometabolic Health, and Body Composition: Findings From the Follow-Up Studies of the INCAP Longitudinal Study.Food and nutrition bulletin · 2020Trial
- Leptin partially mediates the association between early-life nutritional supplementation and long-term glycemic status among women in a Guatemalan longitudinal cohort.The American journal of clinical nutrition · 2020Trial
- The Potential Physiologic Mechanisms by Which Early-Life Nutrition May Influence Type 2 Diabetes Pathophysiology in Humans.Annual review of nutrition · 2026Review
- The Impact of Early-Life Growth on Long-Term Cardiometabolic and Neurocognitive Outcomes in High-Income Countries: A Neglected Public Health Problem.Nutrition reviews · 2026Review
- Life course socioeconomic determinants of multimorbidity in later life: longitudinal evidence from the Health and Retirement Study.Longitudinal and life course studies : international journal · 2026Article
- Epigenetic age and cardiometabolic disease in Guatemalan adults: a cross-sectional analysis.Journal of health, population, and nutrition · 2026Article
- Early-life nutrition supplementation and epigenetic age in middle-adulthood among Guatemalan adults.bioRxiv : the preprint server for biology · 2025Article
- Health status of adults exposed to severe acute malnutrition during childhood in the Eastern Democratic Republic of the Congo: the Lwiro cohort study.BMJ public health · 2025Article
- Micronutrients in early life and offspring metabolic health programming: a promising target for preventing non-communicable diseases.European journal of clinical nutrition · 2023Review
- Barker's Hypothesis Among the Global Poor: Positive Long-Term Cardiovascular Effects of in Utero Famine Exposure.Demography · 2023Article
- Early life predictors of body composition trajectories from adolescence to mid-adulthood.American journal of human biology : the official journal of the Human Biology Council · 2023Article
- Dynamics and consequences of nutrition-related microbial dysbiosis in early life: study protocol of the VITERBI GUT project.Frontiers in nutrition · 2023Article
- Characterising school-age health and function in rural Zimbabwe using the SAHARAN toolbox.PloS one · 2023Article
- The triglyceride glucose index and cardiovascular disease outcomes.The lancet. Healthy longevity · 2023Article
- Nutrient intakes from complementary foods are associated with cardiometabolic biomarkers among undernourished Peruvian children.Journal of nutritional science · 2023Article
Corrections and comments
- Commented on by
- Erratum issued
- Erratum issued
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundLow-income and middle-income countries with populations that are chronically undernourished in early life are undergoing a nutrition transition and are experiencing an epidemic of cardiometabolic disease. These dual burdens are thought to be causally related; therefore, the extent to which improvements in early-life nutrition can offset adult-onset disease is important. The aim of this study was to examine whether improvement of protein-energy nutrition from conception to age 2 years can attenuate the risk of cardiometabolic disease.
methodsWe followed up a cohort of 2392 individuals born between Jan 1, 1962, and Feb 28, 1977, in four villages in Guatemala who had participated in a cluster-randomised protein-energy nutritional supplementation (Atole) trial. Of 1661 participants available for follow-up from Feb 26, 2015, to April 29, 2017, we studied 684 women and 455 men. We assessed cardiometabolic disease risk at ages 37-54 years using anthropometry, fasting and post-challenge glucose, fasting lipid concentrations, and blood pressure. We used generalised linear and logistic regression modelling to estimate the effect of Atole from conception to age 2 years (the first 1000 days) on cardiometabolic disease risk.
findingsExposure to Atole from conception to age 2 years was associated with increased fatness (body-mass index [1·29 kg/m
interpretationImproved protein-energy nutrition from conception to the 2nd birthday reduced the odds of diabetes at ages 37-54 years; however, this protein-energy supplementation also increased the risk of obesity and several obesity-related conditions. Our findings suggest a mixed ability of protein-energy nutritional supplementation in early life to prevent adult cardiometabolic disease incidence in the context of high childhood stunting and high adult overweight and obesity.
fundingNational Institutes of Health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.