Evidence map›Paper›PMID 30012199›Full record

ArticleBMC research notes2018

Cranial neural tube defect after trimethoprim exposure.

Nor Linda Abdullah, Renuka Gunasekaran, Siti Waheeda Mohd-Zin, Bee-Hui Lim, Pramila Maniam, Anis Shuhada Mohd-Salleh, Meow-Keong Thong, Zamri Chik, Noreena Nordin, Zaliha Omar and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Nor Linda AbdullahDepartment of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Renuka GunasekaranDepartment of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Siti Waheeda Mohd-ZinDepartment of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Bee-Hui LimDepartment of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Pramila ManiamDepartment of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Anis Shuhada Mohd-SallehDepartment of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Meow-Keong ThongDepartment of Paediatrics, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Zamri ChikDepartment of Pharmacology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Noreena NordinDepartment of Pharmacology, Faculty of Medicine, University of Malaya Bioequivalence and Testing Centre (UBAT), University of Malaya, 50603, Kuala Lumpur, Malaysia.
Zaliha OmarDepartment of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Julia Patrick EngkasanDepartment of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Dharmendra GanesanDepartment of Surgery, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Zakaria Nurul AiezzahDepartment of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Azlina Ahmad-AnnuarDepartment of Biomedical Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Noraishah Mydin Abdul-AzizDepartment of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. noisha@ummc.edu.my.ORCID http://orcid.org/0000-0002-2447-3211
University of Malaya · MY

Funding

Ministry of Higher Education University of Malaya High Impact Research Grant UM.C/625/1/HIR/MOHE/MED/08University of Malaya High Impact Research Grant UM.C/625/1/HIR/062University of Malaya High Impact Research Grant UM.C/625/1/HIR/148/2University of Malaya Postgraduate Research Grant (PPP) PG137-2015AUniversity of Malaya Postgraduate Research Grant (PPP) PG153-2015B
6 · The paper itself

Abstract

objectivesThe Neural Tube Defects Research Group of University of Malaya was approached to analyze a tablet named TELSE, which may have resulted in a baby born with central nervous system malformation at the University of Malaya Medical Centre. In this animal experimental study, we investigated the content of TELSE and exposure of its contents that resulted in failure of primary neurulation.

resultsLiquid Chromatography Tandem Mass spectrophotometry analysis of the TELSE tablet confirmed the presence of trimethoprim as the active compound. The TELSE tablet-treated females produced significant numbers of embryos with exencephaly (n = 8, 36.4%, *P < 0.0001), in all litters. The TELSE tablet-treated females subsequently given folic acid did not result in pregnancies despite there being evidence of possible resorption. Furthermore, after multiple rounds of mating which did not yield viable pregnancies, eventually, 2 embryos with exencephaly were harvested in a litter of 6 at 0.05% w/v pure trimethoprim once. The use of trimethoprim, a folic acid antagonist, peri-conceptionally increased the risk of exencephaly in the mouse.

Indexed as

AnimalsAnti-Infective Agents, UrinaryFemaleGermanyJapanMalaysiaMaleMiceNeural Tube DefectsPregnancyTaiwanTrimethoprimAnti-Infective Agents, UrinaryTrimethoprimAcneFolic acid antagonistMalaysiaNeural tube defectsPrimary neurulationTrimethoprim

Identifiers

PMID30012199
PMCPMC6048906
OpenAlexW2884605727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.