Evidence map›Paper›PMID 30012195›Full record

ArticleJournal of ovarian research2018

Discordant anti-müllerian hormone (AMH) and follicle stimulating hormone (FSH) among women undergoing in vitro fertilization (IVF): which one is the better predictor for live birth?

Shunping Wang, Yi Zhang, Virginia Mensah, Warren J Huber, Yen-Tsung Huang, Ruben Alvero

Open access · goldAbstract readComparative StudyMulticenter Study
In one paragraph

Article in Journal of ovarian research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shunping WangBrown University Warren Alpert Medical School, Providence, RI, 02912, USA.
Yi ZhangBrown University School of Public Health, Providence, RI, 02912, USA.
Virginia MensahBrown University Warren Alpert Medical School, Providence, RI, 02912, USA.
Warren J HuberBrown University Warren Alpert Medical School, Providence, RI, 02912, USA.
Yen-Tsung HuangBrown University School of Public Health, Providence, RI, 02912, USA. ythuang@stat.sinica.edu.tw.
Ruben AlveroBrown University Warren Alpert Medical School, Providence, RI, 02912, USA. ralvero@wihri.org.
Brown University · USWomen & Infants Hospital of Rhode Island · US

Funding

Integrative Modeling of Gene Expression into GWAS of GliomaR03CA182937 · NCI · TUFTS UNIVERSITY BOSTON · PI HUANG, YEN-TSUNG, MICHAUD, DOMINIQUE S. · 2014 to 2015
$167k
Brown University Population StudiesNational Cancer Institute 5R03CA182937-02NCI NIH HHS R03 CA182937
6 · The paper itself

Abstract

backgroundThis study sought to clarify the roles of Anti-müllerian hormone (AMH) and follicle stimulating hormone (FSH) in predicting live birth, especially in patients with discordant AMH and FSH. A large IVF data set provided by eIVF®, consisting of 13,964 cycles with AMH, FSH, age, BMI, and birth outcomes were evaluated. Patients were categorized into four groups: Good prognosis group (AMH ≥1 ng/ml; FSH < 10 mIU/ml), Poor prognosis group (AMH < 1 ng/ml; FSH ≥10 mIU/ml), Reassuring AMH group (AMH ≥1 ng/ml; FSH ≥10 mIU/ml), and Reassuring FSH group (AMH < 1 ng/ml; FSH < 10 mIU/ml). The interaction between AMH, FSH, and their impact on live birth rate among these four groups was evaluated using Generalized Additive Mixed Modeling (GAMM).

resultsAnalysis revealed a nonlinear relationship of AMH and FSH with live birth rate among all ages. Among the four groups, the good prognosis group had the highest live birth rate while the poor prognosis group had the lowest live birth rate (29.3% vs 13.1%, p < 0.005). In the discordant groups, the live birth rate of the reassuring AMH group was significantly higher than the reassuring FSH group (22.8% vs 15.6%, p < 0.005).

conclusionsAlthough both FSH and AMH are widely use to assess the ovarian reserve in women undergoing evaluation for infertility, AMH appears to be superior to FSH among all age groups. This is particularly important for patients with discordant AMH and FSH where reassuring AMH is a better clinical predictor of cycle success.

Indexed as

Live BirthAdultAge FactorsAnti-Mullerian HormoneFemaleFertilization in VitroFollicle Stimulating HormoneHumansOvarian ReserveOvulation InductionPredictive Value of TestsPregnancyPregnancy OutcomePrognosisReproductive MedicineRetrospective StudiesAnti-Mullerian HormoneFollicle Stimulating Hormone

Identifiers

PMID30012195
PMCPMC6048693
OpenAlexW2883928111

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.