ArticleFluids and barriers of the CNS2018
Pulsatile flow drivers in brain parenchyma and perivascular spaces: a resistance network model study.
Article in Fluids and barriers of the CNS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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Who cites it
48 citing papers in PubMed, 90 citations in OpenAlex.
- In-silico solute transport via perivascular networks in the human intracranial space.Nature communications · 2026Article
- Stretch and flow at the gliovascular interface: High-fidelity modeling of astrocyte endfeet.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mechanistic modeling of amyloid dynamics relating to Alzheimer's disease progression.Frontiers in aging neuroscience · 2026Article
- Dynamic DWI detects respiratory modulation of brain parenchymal hydrodynamics.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Perceiving traumatic brain injury from glymphatic system.Molecular psychiatry · 2025Review
- Perivascular interactions and tissue properties modulate directional glymphatic transport in the brain.Fluids and barriers of the CNS · 2025Article
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- Directional flow in perivascular networks: mixed finite elements for reduced-dimensional models on graphs.Journal of mathematical biology · 2024Article
- Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies.Cellular and molecular life sciences : CMLS · 2024Review
- Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve.Fluids and barriers of the CNS · 2024Article
- The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer's disease continuum participants.Alzheimer's research & therapy · 2024Article
- Hydraulic resistance of three-dimensional pial perivascular spaces in the brain.Fluids and barriers of the CNS · 2024Article
- Image analysis techniques for in vivo quantification of cerebrospinal fluid flow.Experiments in fluids · 2023Article
- Hydraulic resistance of three-dimensional pial perivascular spaces in the brain.Research square · 2023Article
- Image Analysis Techniques for In Vivo Quantification of Cerebrospinal Fluid Flow.bioRxiv : the preprint server for biology · 2023Article
- Sizes and shapes of perivascular spaces surrounding murine pial arteries.Fluids and barriers of the CNS · 2023Article
- Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance.Fluids and barriers of the CNS · 2023Article
- Perivascular network segmentations derived from high-field MRI and their implications for perivascular and parenchymal mass transport in the rat brain.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn animal models, dissolved compounds in the subarachnoid space and parenchyma have been found to preferentially transport through the cortex perivascular spaces (PVS) but the transport phenomena involved are unclear.
methodsIn this study two hydraulic network models were used to predict fluid motion produced by blood vessel pulsations and estimate the contribution made to solute transport in PVS and parenchyma. The effect of varying pulse amplitude and timing, PVS dimensions, and tissue hydraulic conductivity on fluid motion was investigated.
resultsPeriodic vessel pulses resulted in oscillatory fluid motion in PVS and parenchyma but no net flow over time. For baseline parameters, PVS and parenchyma peak fluid velocity was on the order of 10 μm/s and 1 nm/s, with corresponding Peclet numbers below 10
conclusionsSolute transport in parenchyma was predicted to be diffusion dominated, with a negligible contribution from convection. In the PVS, dispersion due to oscillating flow likely plays a significant role in PVS rapid transport observed in previous in vivo experiments. This dispersive effect could be more significant than convective solute transport from net flow that may exist in PVS and should be studied further.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.