ArticleBMC biology2018
A gene regulatory network underlying the formation of pre-placodal ectoderm in Xenopus laevis.
Article in BMC biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Foxi2 and Sox3 are master transcription regulators that control ectoderm germ layer specification in Xenopus.PLoS biology · 2025Article
- Sponge bHLH Gene Expression inInternational journal of molecular sciences · 2025Article
- A time-resolved single-cell roadmap of the logic driving anterior neural crest diversification from neural border to migration stages.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain.iScience · 2023Article
- The sulfotransferase XB5850668.L is required to apportion embryonic ectodermal domains.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border.Development (Cambridge, England) · 2023Article
- Article
- Paracrine regulation of neural crest EMT by placodal MMP28.PLoS biology · 2023Article
- Alcohol induces neural tube defects by reducing retinoic acid signaling and promoting neural plate expansion.Frontiers in cell and developmental biology · 2023Article
- Zmym4 is required for early cranial gene expression and craniofacial cartilage formation.Frontiers in cell and developmental biology · 2023Article
- The homeodomain transcription factor Ventx2 regulates respiratory progenitor cell number and differentiation timing during Xenopus lung development.Development, growth & differentiation · 2022Article
- Feedback Regulation of Signaling Pathways for Precise Pre-Placodal Ectoderm Formation in Vertebrate Embryos.Journal of developmental biology · 2022Review
- Sox8 remodels the cranial ectoderm to generate the ear.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Repressive Interactions Between Transcription Factors Separate Different Embryonic Ectodermal Domains.Frontiers in cell and developmental biology · 2022Article
- NKL Homeobox Genes NKX2-3 and NKX2-4 Deregulate Megakaryocytic-Erythroid Cell Differentiation in AML.International journal of molecular sciences · 2021Article
- Mutations in SIX1 Associated with Branchio-oto-Renal Syndrome (BOR) Differentially Affect Otic Expression of Putative Target Genes.Journal of developmental biology · 2021Article
- Recapitulation of Neural Crest Specification and EMT via Induction from Neural Plate Border-like Cells.Stem cell reports · 2020Article
- Six1 proteins with human branchio-oto-renal mutations differentially affect cranial gene expression and otic development.Disease models & mechanisms · 2020Article
- Building the Border: Development of the Chordate Neural Plate Border Region and Its Derivatives.Frontiers in physiology · 2020Review
- Insights Into the Early Gene Regulatory Network Controlling Neural Crest and Placode Fate Choices at the Neural Border.Frontiers in physiology · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe neural plate border ectoderm gives rise to key developmental structures during embryogenesis, including the neural crest and the preplacodal ectoderm. Many sensory organs and ganglia of vertebrates develop from cranial placodes, which themselves arise from preplacodal ectoderm, defined by expression of transcription factor Six1 and its coactivator Eya1. Here we elucidate the gene regulatory network underlying the specification of the preplacodal ectoderm in Xenopus, and the functional interactions among transcription factors that give rise to this structure.
resultsTo elucidate the gene regulatory network upstream of preplacodal ectoderm formation, we use gain- and loss-of-function studies to explore the role of early ectodermal transcription factors for establishing the preplacodal ectoderm and adjacent ectodermal territories, and the role of Six1 and Eya1 in feedback regulation of these transcription factors. Our findings suggest that transcription factors with expression restricted to ventral (non-neural) ectoderm (AP2, Msx1, FoxI1, Vent2, Dlx3, GATA2) and those restricted to dorsal (neural) ectoderm (Pax3, Hairy2b, Zic1) are required for specification of both preplacodal ectoderm and neural crest in a context-dependent fashion and are cross-regulated by Eya1 and Six1.
conclusionThese findings allow us to elucidate a detailed gene regulatory network at the neural plate border upstream of preplacodal ectoderm formation based on functional interactions between ectodermal transcription factors. We propose a new model to explain the formation of immediately juxtaposed preplacodal ectoderm and neural crest territories at the neural plate border, uniting previous models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.