Evidence map›Paper›PMID 30012110›Full record

ArticleBMC infectious diseases2018

Feasibility and acceptability of home-based HIV testing among refugees: a pilot study in Nakivale refugee settlement in southwestern Uganda.

Kelli N O'Laughlin, Wei He, Kelsy E Greenwald, Julius Kasozi, Yuchiao Chang, Edgar Mulogo, Zikama M Faustin, Patterson Njogu, Rochelle P Walensky, Ingrid V Bassett

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Kelli N O'LaughlinDepartment of Emergency Medicine, Brigham & Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. kolaughlin@bwh.harvard.edu.ORCID 0000-0003-3027-1883
Wei HeDivision of General Medicine, Massachusetts General Hospital, 50 Staniford St, Suite 560, Boston, MA, 02114-2698, USA.
Kelsy E GreenwaldHarvard Affiliated Emergency Medicine Residency, 75 Francis Street, Boston, MA, 02115, USA.
Julius KasoziUnited Nations High Commissioner for Refugees, Representation in Uganda, P.O. Box 3813, Kampala, Uganda.
Yuchiao ChangHarvard Medical School, Boston, MA, 02114-2698, USA.
Edgar MulogoDepartment of Community Health, Mbarara University of Science and Technology, P.O Box 1410, Mbarara, Uganda.
Zikama M FaustinBugema University, Kasese Campus, P.O. Box 6529, Kampala, Uganda.
Patterson NjoguUnited Nations High Commissioner for Refugees, Representation in Kenya, P.O. Box 43801-00100, Nairobi, Kenya.
Rochelle P WalenskyMedical Practice Evaluation Center, Department of Medicine, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, MA, 02114-2698, USA.
Ingrid V BassettMedical Practice Evaluation Center, Department of Medicine, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, MA, 02114-2698, USA.
Brigham and Women's Hospital · USHarvard University · USBugema University · UGHarvard Affiliated Emergency Medicine Residency · USMassachusetts General Hospital · USMbarara University of Science and Technology · UGOffice of the United Nations High Commissioner for Refugees · CH

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Novel Methods to Inform HIV/TB Clinical Trial DevelopmentR37AI093269 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI WALENSKY, ROCHELLE P. · 2015 to 2019
$3.8M
What happens after diagnosis: Characterizing long-term HIV care trajectories and mortality in South AfricaR01MH108427 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BASSETT, INGRID VALERIE · 2016 to 2019
$1.7M
Linking Refugees to HIV Clinical Care in UgandaK23MH108440 · NIMH · UNIVERSITY OF WASHINGTON · PI O'LAUGHLIN, KELLI NICOLE · 2016 to 2020
$990k
Harvard University Center for AIDS Research NIH/NIAID 5P30AI060354NIAID NIH HHS P30 AI060354NIAID NIH HHS R37 AI093269NIMH NIH HHS K23 MH108440NIMH NIH HHS R01 MH108427NIMH NIH HHS R01MH108427
6 · The paper itself

Abstract

backgroundRefugees in sub-Saharan Africa face both the risk of HIV infection and barriers to HIV testing. We conducted a pilot study to determine the feasibility and acceptability of home-based HIV testing in Nakivale Refugee Settlement in Uganda and to compare home-based and clinic-based testing participants in Nakivale.

methodsFrom February-March 2014, we visited homes in 3 villages in Nakivale up to 3 times and offered HIV testing. We enrolled adults who spoke English, Kiswahili, Kinyarwanda, or Runyankore; some were refugees and some Ugandan nationals. We surveyed them about their socio-demographic characteristics. We evaluated the proportion of individuals encountered (feasibility) and assessed participation in HIV testing among those encountered (acceptability). We compared characteristics of home-based and clinic-based testers (from a prior study in Nakivale) using Wilcoxon rank sum and Pearson's chi-square tests. We examined the relationship between a limited number of factors (time of visit, sex, and number of individuals at home) on willingness to test, using logistic regression models with the generalized estimating equations approach to account for clustering.

resultsOf 566 adults living in 319 homes, we encountered 507 (feasibility = 90%): 353 (62%) were present at visit one, 127 (22%) additional people at visit two, and 27 (5%) additional people at visit three. Home-based HIV testing participants totaled 378 (acceptability = 75%). Compared to clinic-based testers, home-based testers were older (median age 30 [IQR 24-40] vs 28 [IQR 22-37], p < 0.001), more likely refugee than Ugandan national (93% vs 79%, < 0.001), and more likely to live ≥1 h from clinic (74% vs 52%, < 0.001). The HIV prevalence was lower, but not significantly, in home-based compared to clinic-based testing participants (1.9 vs 3.4% respectively, p = 0.27). Testing was not associated with time of visit (p = 0.50) or sex (p = 0.66), but for each additional person at home, the odds of accepting HIV testing increased by over 50% (OR 1.52, 95%CI 1.12-2.06, p = 0.007).

conclusionsHome-based HIV testing in Nakivale Refugee Settlement was feasible, with 90% of eligible individuals encountered within 3 visits, and acceptable with 75% willing to test for HIV, with a yield of nearly 2% individuals tested identified as HIV-positive.

Indexed as

Direct-To-Consumer Screening and TestingReagent Kits, DiagnosticRefugeesAdultChi-Square DistributionFeasibility StudiesFemaleHIV InfectionsHumansLogistic ModelsMaleMiddle AgedPilot ProjectsPrevalenceSurveys and QuestionnairesUgandaReagent Kits, DiagnosticDisplaced populationHIVHIV testingHome-based HIV testingHumanitarianRefugeesUganda

Identifiers

PMID30012110
PMCPMC6048800
OpenAlexW2884814759

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.