Evidence map›Paper›PMID 30012052›Full record

ArticleMotor control2019

Brain Activation During Passive and Volitional Pedaling After Stroke.

Brice T Cleland, Sheila Schindler-Ivens

Abstract read
In one paragraph

Article in Motor control, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brice T ClelandMarquette University.
Sheila Schindler-IvensMarquette University.

Funding

Cortical priming to optimize gait rehabilitation post strokeR01HD075777 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MADHAVAN, SANGEETHA · 2014 to 2024
$4.1M
Supraspinal Contributions to Locomotor Control and Recovery after StrokeK01HD060693 · NICHD · MARQUETTE UNIVERSITY · PI SCHINDLER-IVENS, SHEILA M · 2010 to 2014
$579k
American Heart Association-American Stroke Association 16PRE26650000NICHD NIH HHS K01 HD060693NICHD NIH HHS R01 HD075777
6 · The paper itself

Abstract

backgroundPrior work indicates that pedaling-related brain activation is lower in people with stroke than in controls. We asked whether this observation could be explained by between-group differences in volitional motor commands and pedaling performance.

methodsIndividuals with and without stroke performed passive and volitional pedaling while brain activation was recorded with functional magnetic resonance imaging. The passive condition eliminated motor commands to pedal and minimized between-group differences in pedaling performance. Volume, intensity, and laterality of brain activation were compared across conditions and groups.

resultsThere were no significant effects of condition and no Group × Condition interactions for any measure of brain activation. Only 53% of subjects could minimize muscle activity for passive pedaling.

conclusionsAltered motor commands and pedaling performance are unlikely to account for reduced pedaling-related brain activation poststroke. Instead, this phenomenon may be due to functional or structural brain changes. Passive pedaling can be difficult to achieve and may require inhibition of excitatory descending drive.

Indexed as

BrainElectromyographyFemaleHumansMaleMiddle AgedMuscle, SkeletalStrokeelectromyographyfMRIhemiparesislocomotionneuroplasticityrehabilitation

Identifiers

PMID30012052
PMCPMC6685765

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.