Evidence map›Paper›PMID 30011953›Full record

ArticleMolecules (Basel, Switzerland)2018

Development of Conjugate Addition of Lithium Dialkylcuprates to Thiochromones: Synthesis of 2-Alkylthiochroman-4-ones and Additional Synthetic Applications.

Shekinah A Bass, Dynasty M Parker, Tania J Bellinger, Aireal S Eaton, Angelica S Dibble, Kaata L Koroma, Sylvia A Sekyi, David A Pollard, Fenghai Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shekinah A BassDepartment of Chemistry, Winston Salem State University, 601 S. Martin Luther King Jr. Dr., Winston Salem, NC 27110, USA. sbass116@rams.wssu.edu.
Dynasty M ParkerDepartment of Chemistry, Winston Salem State University, 601 S. Martin Luther King Jr. Dr., Winston Salem, NC 27110, USA. dparker115@rams.wssu.edu.
Tania J BellingerDepartment of Chemistry, Winston Salem State University, 601 S. Martin Luther King Jr. Dr., Winston Salem, NC 27110, USA. tbellinger115@rams.wssu.edu.
Aireal S EatonDepartment of Chemistry, Winston Salem State University, 601 S. Martin Luther King Jr. Dr., Winston Salem, NC 27110, USA. aeaton114@rams.wssu.edu.
Angelica S DibbleDepartment of Chemistry, Winston Salem State University, 601 S. Martin Luther King Jr. Dr., Winston Salem, NC 27110, USA. adibble114@rams.wssu.edu.
Kaata L KoromaDepartment of Chemistry, Winston Salem State University, 601 S. Martin Luther King Jr. Dr., Winston Salem, NC 27110, USA. kkoroma116@rams.wssu.edu.
Sylvia A SekyiDepartment of Chemistry, Winston Salem State University, 601 S. Martin Luther King Jr. Dr., Winston Salem, NC 27110, USA. ssekyi116@rams.wssu.edu.
David A PollardDepartment of Chemistry, Winston Salem State University, 601 S. Martin Luther King Jr. Dr., Winston Salem, NC 27110, USA. pollardda@wssu.edu.
Fenghai GuoDepartment of Chemistry, Winston Salem State University, 601 S. Martin Luther King Jr. Dr., Winston Salem, NC 27110, USA. guof@wssu.edu.ORCID 0000-0001-9099-0965

Funding

Winston-Salem State University Research Initiative for Scientific EnhancementR25GM113774 · NIGMS · WINSTON-SALEM STATE UNIVERSITY · PI YAKUBU, MAMUDU · 2015 to 2019
$1.9M
NIGMS NIH HHS R25 GM113774
6 · The paper itself

Abstract

Lithium dialkylcuprates undergo conjugate addition to thiochromones to afford 2-alkylthiochroman-4-ones in good yields. This approach provide an efficient and general synthetic approach to privileged sulfur-containing structural motifs and valuable precursors for many pharmaceuticals, starting from common substrates-thiochromones. Good yields of 2-alkyl-substituted thiochroman-4-ones are attained with lithium dialkylcuprates, lithium alkylcyanocuprates or substoichiometric amount of copper salts. The use of commercially available inexpensive alkyllithium reagents will expedite the synthesis of a large library of 2-alkyl substituted thiochroman-4-ones for additional synthetic applications.

Indexed as

ChromonesCopperLithiumOrganometallic CompoundsChromonesCopperLithiumOrganometallic Compounds2-alkylthiochroman-4-onesconjugate additionlithium dialkyl cupratesthiochroman-4-onesthiochromones

Identifiers

PMID30011953
PMCPMC6099951

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.