Evidence map›Paper›PMID 30011814›Full record

ArticleDiseases (Basel, Switzerland)2018

Host Protein BAG3 is a Negative Regulator of Lassa VLP Egress.

Ziying Han, Michael P Schwoerer, Philip Hicks, Jingjing Liang, Gordon Ruthel, Corbett T Berry, Bruce D Freedman, Cari A Sagum, Mark T Bedford, Sachdev S Sidhu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Diseases (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Host BAG3 Is Degraded by Pseudorabies Virus pUL56 C-TerminalInternational journal of molecular sciences · 2020
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Ziying HanDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ziying@vet.upenn.edu.
Michael P SchwoererDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. mschwo@sas.upenn.edu.
Philip HicksDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. hicksph@vet.upenn.edu.
Jingjing LiangDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. jiliang@vet.upenn.edu.
Gordon RuthelDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. goruthel@vet.upenn.edu.
Corbett T BerryDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. corbettb@vet.upenn.edu.ORCID 0000-0001-9348-2034
Bruce D FreedmanDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. bruce@vet.upenn.edu.
Cari A SagumDepartment of Epigenetics & Molecular Carcinogenesis, M.D. Anderson Cancer Center, University of Texas, Smithville, TX 78957, USA. casagum@mdanderson.org.
Mark T BedfordDepartment of Epigenetics & Molecular Carcinogenesis, M.D. Anderson Cancer Center, University of Texas, Smithville, TX 78957, USA. mtbedford@mdanderson.org.ORCID 0000-0002-8899-1050
Sachdev S SidhuDepartment of Molecular Genetics, University of Toronto, Toronto, ON M1C 1A4, Canada. sachdev.sidhu@utoronto.ca.
Marius SudolDepartment of Physiology, Institute for Molecular and Cell Biology (IMCB, AStar), National University of Singapore, Singapore 119077, Singapore. phsms@nus.edu.sg.
Ronald N HartyDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. rharty@vet.upenn.edu.
University of Pennsylvania · USThe University of Texas MD Anderson Cancer Center · USNational University of Singapore · SGUniversity of Toronto · CA

Funding

VMD-PhD Training in Infectious Disease-Related ResearchT32AI070077 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Michael Lee Atchison · 2008 to 2026
$3.5M
Modular Domains of Host Proteins Regulate Filovirus MaturationR21AI138052 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HARTY, RONALD N · 2018 to 2019
$448k
Host-Oriented Therapeutics Targeting Filovirus Budding.R21AI102104 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HARTY, RONALD N · 2012 to 2013
$423k
NIAID NIH HHS R21 AI102104NIAID NIH HHS R21 AI138052NIAID NIH HHS T32 AI070077
6 · The paper itself

Abstract

Lassa fever virus (LFV) belongs to the

Indexed as

autophagyBAG3buddingEbolaLassa fever virusL-domainvirus-host interactionVLPsWW-domain

Identifiers

PMID30011814
PMCPMC6163595
OpenAlexW2883638492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.