ArticleAnnals of the American Thoracic Society2018
Restrictive Spirometry Pattern, Cardiac Structure and Function, and Incident Heart Failure in African Americans. The Jackson Heart Study.
Article in Annals of the American Thoracic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Association of preserved ratio impaired spirometry with mortality: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Significant Spirometric Transitions and Preserved Ratio Impaired Spirometry Among Ever Smokers.Chest · 2022Trial
- Low appendicular muscle mass and the risk of COPD development in people with PRISm.ERJ open research · 2026Article
- Frailty as a Key Determinant of Cardiovascular Risk and Mortality in Preserved Ratio Impaired Spirometry: A Nationally Representative Study.The clinical respiratory journal · 2026Article
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- Spirometric pattern and cardiovascular risk: a prospective study of 0.3 million Chinese never-smokers.The Lancet regional health. Western Pacific · 2025Article
- Association between estimated glucose disposal rate and preserved ratio impaired spirometry in adults.Frontiers in endocrinology · 2025Article
- Risk of All-Cause Mortality in US Adults With Preserved Ratio Impaired Spirometry: An Observational Study.International journal of chronic obstructive pulmonary disease · 2025Observational
- Article
- Article
- Acute Exacerbation and Longitudinal Lung Function Change of Preserved Ratio Impaired Spirometry.International journal of chronic obstructive pulmonary disease · 2024Article
- COVID-19 and persistent symptoms: implications for polycystic ovary syndrome and its management.Frontiers in endocrinology · 2024Review
- Changes in Pulmonary Artery Pressure Late in Life: The Atherosclerosis Risk in Communities (ARIC) Study.Journal of the American College of Cardiology · 2023Article
- Associations between environmental heavy metals exposure and preserved ratio impaired spirometry in the U.S. adults.Environmental science and pollution research international · 2023Article
- Association of spirometric restriction with mortality in the silicotics: a cohort study.BMC pulmonary medicine · 2023Article
- The relationship between preserved ratio impaired spirometry and mortality in the myocardial infarction survivors: a population-based cohort study.BMC cardiovascular disorders · 2023Article
- Longitudinal mortality of preserved ratio impaired spirometry in a middle-aged Asian cohort.BMC pulmonary medicine · 2023Article
- Preserved ratio impaired spirometry with or without restrictive spirometric abnormality.Scientific reports · 2023Article
- Principal component analysis of flow-volume curves in COPDGene to link spirometry with phenotypes of COPD.Respiratory research · 2023Article
- Trajectories of Spirometric Patterns, Obstructive and PRISm, in a Population-Based Cohort in Latin America.International journal of chronic obstructive pulmonary disease · 2023Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
rationaleAlthough chronic obstructive pulmonary disease has been related to heart failure, the relationship between the restrictive spirometry pattern (forced vital capacity [FVC] < 80% predicted with preserved forced expiratory volume in 1 second [FEV
objectivesTo determine whether having a restrictive spirometry pattern is associated with incident heart failure hospitalization.
methodsCommunity-dwelling African Americans from the Jackson Heart Study (total n = 5,306; analyzed n = 4,210 with spirometry and heart failure outcome data) were grouped by restrictive spirometry (FEV
resultsAt the time of baseline spirometry, participants with restrictive spirometry had a median age of 57.2 years (interquartile range, 47.8-64.1); 38.1% were male. Compared with normal spirometry, restrictive spirometry was associated with a higher transmitral early (E) wave velocity to atrial (A) wave velocity ratio, higher pulmonary artery systolic pressure, and higher endothelin levels. After a median follow-up time of 8.0 years, 8.0% of subjects with restrictive spirometry (n = 67) had developed incident heart failure, compared with 3.8% of those with normal spirometry (n = 115) and 10.6% of those with airflow obstruction (n = 36). After risk adjustment, both a restrictive pattern (hazard ratio [HR], 1.5; 95% confidence interval [CI], 1.1-2.0) and airflow obstruction (HR, 1.7; 95% CI, 1.1-2.5) were associated with increased rates of incident heart failure hospitalization compared with normal spirometry. Using flexible modeling, the lowest hazards of heart failure hospitalization were observed around FVC 90-100%, with lower FVC% values associated with an increased incidence of heart failure.
conclusionsBoth a restrictive pattern on spirometry and airflow obstruction identify African Americans with impaired lung health at risk for heart failure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.