Trial reportPloS one2018
A standardized protocol for quantification of saccadic eye movements: DEMoNS.
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06629155 (Disentangling Cognitive Functioning and Visual Scanning Deficits in Cognitive Test Results in Multiple Sclerosis), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Disentangling Cognitive Functioning and Visual Scanning Deficits in Cognitive Test Results in Multiple Sclerosis (MS)
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Eye Tracking Studies Exploring Cognitive and Affective Processes among Alcohol Drinkers: a Systematic Review and Perspectives.Neuropsychology review · 2021Pooled it
- Treatment of internuclear ophthalmoparesis in multiple sclerosis with fampridine: A randomized double-blind, placebo-controlled cross-over trial.CNS neuroscience & therapeutics · 2019Trial
- A Data-Driven Operational Definition of Square-Wave Jerks and Its Diagnostic Utility in Progressive Supranuclear Palsy.European journal of neurology · 2026Article
- Advanced Eye Movement Features Measured by Quantitative Oculography as Candidate Biomarkers for Progressive Supranuclear Palsy.Diagnostics (Basel, Switzerland) · 2026Review
- Eye movements and ocular biomarkers in mild traumatic brain injury: from oculomotor pathophysiology to diagnosis and prognosis.Journal of neurology · 2026Review
- Global Rather Than Vertical-Selective Saccadic Abnormalities in Progressive Supranuclear Palsy.Annals of clinical and translational neurology · 2026Article
- What if it is the eyes? The effect of eye movement disorders on cognitive testing in MS.Journal of neurology · 2026Article
- Instability of Oculomotor Control in Parkinson's Disease Without Freezing of Gait: Evidence From Reflexive and Voluntary Saccade Variability.The European journal of neuroscience · 2026Article
- Technical validation of a virtual reality-based eye tracker for neuro-ophthalmic assessment: a reliability and reproducibility study.Scientific reports · 2026Article
- Article
- Saccadic eye movements in neurological disease: cognitive mechanisms and clinical applications.Journal of neurology · 2025Review
- Repeatability, reliability, and stability of eye movement measurements in Parkinson's disease, cerebellar ataxia, and healthy adults.Frontiers in neurology · 2025Article
- Augmenting early stroke diagnosis with an eye-tracker.Frontiers in neurology · 2025Article
- Effects of Cervical Spinal Manipulation on Saccadic Eye Movements.Brain sciences · 2024Article
- Measuring and predicting the effect of remyelinating therapy in multiple sclerosis: a randomised controlled trial protocol (RESTORE).BMJ open · 2024Article
- Visual outcome measures in clinical trials of remyelinating drugs.BMJ neurology open · 2024Review
- A novel eye-movement impairment in multiple sclerosis indicating widespread cortical damage.Brain : a journal of neurology · 2023Article
- Eye Movements in Mild Traumatic Brain Injury: Ocular Biomarkers.Journal of eye movement research · 2022Article
- Eye Movement Abnormalities in Glaucoma Patients: A Review.Eye and brain · 2022Review
- Oculomotor deficits in Parkinson's disease: Increasing sensitivity using multivariate approaches.Frontiers in digital health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveQuantitative saccadic testing is a non-invasive method of evaluating the neural networks involved in the control of eye movements. The aim of this study is to provide a standardized and reproducible protocol for infrared oculography measurements of eye movements and analysis, which can be applied for various diseases in a multicenter setting.
methodsDevelopment of a protocol to Demonstrate Eye Movement Networks with Saccades (DEMoNS) using infrared oculography. Automated analysis methods were used to calculate parameters describing the characteristics of the saccadic eye movements. The two measurements of the subjects were compared with descriptive and reproducibility statistics.
resultsInfrared oculography measurements of all subjects were performed using the DEMoNS protocol and various saccadic parameters were calculated automatically from 28 subjects. Saccadic parameters such as: peak velocity, latency and saccade pair ratios showed excellent reproducibility (intra-class correlation coefficients > 0.9). Parameters describing performance of more complex tasks showed moderate to good reproducibility (intra-class correlation coefficients 0.63-0.78).
conclusionsThis study provides a standardized and transparent protocol for measuring and analyzing saccadic eye movements in a multicenter setting. The DEMoNS protocol details outcome measures for treatment trial which are of excellent reproducibility. The DEMoNS protocol can be applied to the study of saccadic eye movements in various neurodegenerative and motor diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.