ArticlePloS one2018
Time course of traumatic neuroma development.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 105 citations in OpenAlex.
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- Painful neuromas exhibit axonal phenotypic shift via nociceptive and mechanosensitive marker up-regulation.PNAS nexus · 2026Article
- Application strategies of autologous and decellularized nerve grafts: Structural and functional recovery.Neural regeneration research · 2026Article
- Neuroma Prevention with a Novel In Situ Forming Hydrogel in a Rat Sciatic Nerve Model.Plastic and reconstructive surgery. Global open · 2026Article
- Characterizing neuroma-like formation after tail docking in sheep.Research in veterinary science · 2026Article
- Roles of the Complement System in Peripheral Nerve Injury and Repair.Bioengineering (Basel, Switzerland) · 2026Review
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- Neuroma Prevention by Nerve to Artery Coaptation: A Pilot Study.Journal of hand surgery global online · 2026Article
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- A Novel Hydrogel for Treatment and Prevention of Symptomatic Neuroma: Early Clinical Experience.Plastic and reconstructive surgery. Global open · 2025Article
- High-Resolution Ultrasound of Clinically Relevant Sensory Nerves of the Arm and the Forearm.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Eco-Friendly Approaches to Azo Dye Removal: The Role of Microbial Azo-Reductases.Applied biochemistry and biotechnology · 2025Review
- Prevention of nerve growth and evoked pain with a nerve cap graft device.NPJ Regenerative medicine · 2025Article
- Pain without presence: a narrative review of the pathophysiological landscape of phantom limb pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- The Effect of Surgical Timing on Upper Extremity Nerve Repair.Hand (New York, N.Y.) · 2025Article
- Diagnosis and Management of Neuropathic Breast Pain.Plastic and reconstructive surgery. Global open · 2024Article
- Pain After Lower Limb Amputations: Insights from the Heidelberg Amputation Registry.Medicina (Kaunas, Lithuania) · 2024Article
- Neuroma Analysis in Humans: Standardizing Sample Collection and Documentation.The Journal of surgical research · 2024Article
- Traumatic neuromas with hemangiomas of diverse morphology in the left upper arm: a case description.Quantitative imaging in medicine and surgery · 2024Article
- Chronic Unilateral Headache Related to Scar Neuromas.Journal of medical cases · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was designed to characterize morphologic stages during neuroma development post amputation with an eye toward developing better treatment strategies that intervene before neuromas are fully formed. Right forelimbs of 30 Sprague Dawley rats were amputated and limb stumps were collected at 3, 7, 28, 60 and 90 Days Post Amputation (DPA). Morphology of newly formed nerves and neuromas were assessed via general histology and neurofilament protein antibody staining. Analysis revealed six morphological characteristics during nerve and neuroma development; 1) normal nerve, 2) degenerating axons, 3) axonal sprouts, 4) unorganized bundles of axons, 5) unorganized axon growth into muscles, and 6) unorganized axon growth into fibrotic tissue (neuroma). At early stages (3 & 7 DPA) after amputation, normal nerves could be identified throughout the limb stump and small areas of axonal sprouts were present near the site of injury. Signs of degenerating axons were evident from 7 to 90 DPA. From day 28 on, variability of nerve characteristics with signs of unorganized axon growth into muscle and fibrotic tissue and neuroma formation became visible in multiple areas of stump tissue. These pathological features became more evident on days 60 and 90. At 90 DPA frank neuroma formation was present in all stump tissue. By following nerve regrowth and neuroma formation after amputation we were able to identify 6 separate histological stages of nerve regrowth and neuroma development. Axonal regrowth was observed as early as 3 DPA and signs of unorganized axonal growth and neuroma formation were evident by 28 DPA. Based on these observations we speculate that neuroma treatment and or prevention strategies might be more successful if targeted at the initial stages of development and not after 28 DPA.
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