ArticlePLoS neglected tropical diseases2018
Grade 2 disabilities in leprosy patients from Brazil: Need for follow-up after completion of multidrug therapy.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic Review of Survival Analysis in Leprosy Studies-Including the Following Outcomes: Relapse, Impairment of Nerve Function, Reactions and Physical Disability.International journal of environmental research and public health · 2022Pooled it
- Delayed detection of leprosy cases: A systematic review of healthcare-related factors.PLoS neglected tropical diseases · 2022Pooled it
- Individual and community factors determining delayed leprosy case detection: A systematic review.PLoS neglected tropical diseases · 2021Pooled it
- Geospatial inequalities in severe leprosy disability in Pernambuco before and during COVID-19.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases · 2026Article
- Article
- Endemicity, disability and neglect: Leprosy in Colombia 2007-2020.PLoS neglected tropical diseases · 2025Article
- Evaluating Machine Learning Models for Predicting Late Leprosy Diagnosis by Physical Disability Grade in Brazil (2018-2022).Tropical medicine and infectious disease · 2025Article
- Potentially disabling factors of newly diagnosed leprosy patients in southwest China: a retrospective observational study.BMC public health · 2025Observational
- Progression of the leprosy reaction and nerve damage: A prospective cohort study in children with leprosy from the Brazilian Amazon.PLoS neglected tropical diseases · 2024Article
- Frequency and Factors Associated with Disabilities among Leprosy Patients Admitted to the Kindia Disability Prevention and Physical Rehabilitation Centre (Pirp) in Guinea from 2017 to 2021.Tropical medicine and infectious disease · 2024Article
- Burden of leprosy and associated risk factors for disabilities in Tanzania from 2017 to 2020.PloS one · 2024Article
- Temporal trends and spatial analysis of leprosy surveillance indicators in the municipalities of the state of Mato Grosso, 2008-2022.Revista da Sociedade Brasileira de Medicina Tropical · 2024Article
- Prevalence and risk factors for disability in leprosy patients in Indonesia during the post-elimination era.Dermatology reports · 2023Article
- Epidemiology and grade 2 disability of leprosy among migrant and resident patients in Guangdong: an unignorable continued transmission of leprosy.Frontiers in public health · 2023Article
- The burden of physical disability among patients with newly detected leprosy in Yunnan, China, 1990-2020: A population-based, cross-sectional survey.PLoS neglected tropical diseases · 2022Article
- Understanding leprosy reactions and the impact on the lives of people affected: An exploration in two leprosy endemic countries.PLoS neglected tropical diseases · 2022Article
- The life experience of leprosy families in maintaining interaction patterns in the family to support healing in leprosy patients in Indonesian society. A phenomenological qualitative study.PLoS neglected tropical diseases · 2022Article
- Clinical, epidemiological, and laboratory prognostic factors in patients with leprosy reactions: A 10-year retrospective cohort study.Frontiers in medicine · 2022Article
- Risk factors for physical disability in patients with leprosy disease in Yunnan, China: Evidence from a retrospective observational study.PLoS neglected tropical diseases · 2021Observational
- The state of the leprosy epidemic in Yunnan, China 2011-2020: A spatial and spatiotemporal analysis, highlighting areas for intervention.PLoS neglected tropical diseases · 2021Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLeprosy continues to be a public health problem in many countries. Difficulties faced by health services include late diagnosis, under-reporting of new cases, adequate monitoring of disabilities and treatment. Furthermore, systematic follow-up after completion of treatment is important, when new disabilities may occur, or existing disabilities may get worse. The objective of the present study was to determine the prevalence of leprosy-associated grade 2 disabilities (G2D) after completion of multidrug therapy (MDT) and to identify factors associated with G2D.
methodsWe performed a cross-sectional study of 222 leprosy cases registered in Vitória da Conquista, Bahia state, Brazil from 2001-2014. We performed a clinical examination of the study participants and collected socio-economic and clinical information by interview. We identified factors associated with grade 2 disability (G2D) using logis tic regression.
resultsIn total, 38 (17.1%) participants were diagnosed with G2D, and 106 (47.7%) with grade 1 disabilities (G1D). The following independent factors were significantly associated with G2D: occurrence of leprosy reaction (adjusted OR = 2.5; 95%CI = 1.09-5.77), thickening and/or tenderness of one or more nerve trunks (adjusted OR = 3.0; CI = 1.13-8.01) and unemployment (adjusted OR = 7.17; CI = 2.44-21.07).
conclusionsThis study shows that physical disabilities remain after completion of MDT and frequently occur in an endemic area in Brazil. Finding new ways to reduce the burden of disability are urgently needed, and may include systematic follow-up of patients after treatment completion combined with evidence-based preventative measures.
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